{"id":"W4378515069","doi":"10.3390/ph16050700","title":"Synergistic Effect of Anethole and Platinum Drug Cisplatin against Oral Cancer Cell Growth and Migration by Inhibiting MAPKase, Beta-Catenin, and NF-κB Pathways","year":2023,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Al-Imam Muhammad Ibn Saud Islamic University; Imam Mohammed Ibn Saud Islamic University; Université Laval","keywords":"Cisplatin; Chemistry; Cancer cell; Apoptosis; Cell growth; Cytotoxicity; Viability assay; Pharmacology; Cancer research; MTT assay; Anethole; Reactive oxygen species; Cancer; Biochemistry; Biology; Medicine; In vitro; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009862268,0.0003962672,0.0004701189,0.0004391504,0.0001595898,0.0002037599,0.0001783612,0.0002276444,0.001067478],"category_scores_gemma":[0.0001151583,0.0001422462,0.0003724397,0.0001805942,0.0001177574,0.0002218727,0.0002921938,0.000433341,0.0001429516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001340265,"about_ca_system_score_gemma":0.0002512594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002487221,"about_ca_topic_score_gemma":0.0009837502,"domain_scores_codex":[0.9998795,0.00002541909,0.00001485698,0.00002322523,0.00003475366,0.0000221667],"domain_scores_gemma":[0.9999419,0.00001143889,0.00001212056,0.000006334024,0.000009846113,0.00001817015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009010743,0.0004879428,0.0005548108,0.0004981285,0.00008005687,0.0002094371,0.0000380155,0.0004821178,0.9748644,0.0001399027,0.0003589668,0.02138505],"study_design_scores_gemma":[0.0003078731,0.008591045,0.01221998,0.00006790866,0.0003004741,0.00106103,0.00007712258,0.002337599,0.9607267,0.0002302956,0.0140522,0.00002776103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801456,0.01324487,0.002290089,0.0002528748,0.0001415776,0.0001527114,0.0001648617,0.00007704469,0.003530254],"genre_scores_gemma":[0.9877772,0.007026962,0.002821649,0.0001515221,0.00004853292,0.0001117672,0.0001962111,0.000009371239,0.001856838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001067478,"threshold_uncertainty_score":0.003571093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01684770219661966,"score_gpt":0.2914754078364865,"score_spread":0.2746277056398668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}