{"id":"W4378515069","doi":"10.3390/ph16050700","title":"Synergistic Effect of Anethole and Platinum Drug Cisplatin against Oral Cancer Cell Growth and Migration by Inhibiting MAPKase, Beta-Catenin, and NF-κB Pathways","year":2023,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Al-Imam Muhammad Ibn Saud Islamic University; Imam Mohammed Ibn Saud Islamic University; Université Laval","keywords":"Cisplatin; Chemistry; Cancer cell; Apoptosis; Cell growth; Cytotoxicity; Viability assay; Pharmacology; Cancer research; MTT assay; Anethole; Reactive oxygen species; Cancer; Biochemistry; Biology; Medicine; In vitro; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003061648,0.0002142593,0.0002776,0.00003260851,0.00008397353,0.00002996529,0.0000659182,0.00009989991,0.00001128909],"category_scores_gemma":[0.00009934303,0.0001965585,0.00003668287,0.0000767417,0.000202731,0.00001054256,0.0001556053,0.0001061181,0.000002163392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007823231,"about_ca_system_score_gemma":0.00001701456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005189057,"about_ca_topic_score_gemma":0.00001827923,"domain_scores_codex":[0.9988235,0.0001282532,0.0002671226,0.0004065443,0.0001037832,0.0002708279],"domain_scores_gemma":[0.9994451,0.000152318,0.0001150553,0.00009113539,0.00004661902,0.0001497468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009828717,0.00001714887,0.008064607,0.000306624,0.00003647299,0.000002662182,0.0001368944,0.000009376009,0.9871764,0.00001115819,0.00123831,0.002902091],"study_design_scores_gemma":[0.001046881,0.0001039619,0.0006100301,0.00003694215,0.00007416947,0.000001723742,0.00007454353,0.0008845865,0.9963169,0.00004679599,0.0005928903,0.0002105475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943002,0.00452164,0.00005331511,0.0001353394,0.00003991077,0.000265002,0.0003259559,0.00001772463,0.0003409013],"genre_scores_gemma":[0.9964516,0.002702848,0.0001457686,0.0001205686,0.00007989765,0.00004073519,0.0003270269,0.00002524691,0.0001063347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009140559,"threshold_uncertainty_score":0.8015422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01684770219661966,"score_gpt":0.2914754078364865,"score_spread":0.2746277056398668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}