{"id":"W4378515347","doi":"10.3390/medicina59050945","title":"The Use of F-18 FDG PET-Based Cognitive Reserve to Evaluate Cognitive Decline in Alzheimer’s Disease, Independent of Educational Influence","year":2023,"lang":"en","type":"article","venue":"Medicina","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Cognitive reserve; Clinical Dementia Rating; Dementia; Cognition; Standardized uptake value; Psychology; Demographics; Cognitive decline; Positron emission tomography; Alzheimer's disease; Mini–Mental State Examination; Medicine; Disease; Internal medicine; Audiology; Neuroscience; Cognitive impairment; Demography","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008206204,0.0003919938,0.0002399754,0.001292869,0.0001600272,0.0005627298,0.0002424066,0.0002947533,0.0006061846],"category_scores_gemma":[0.001095997,0.00008712424,0.0002118272,0.0004530237,0.0002164505,0.0003022066,0.0001686841,0.0002126313,0.0001514391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001936723,"about_ca_system_score_gemma":0.0001406664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001392928,"about_ca_topic_score_gemma":0.002498926,"domain_scores_codex":[0.9998326,0.00004992804,0.00002270057,0.00003718087,0.00003298217,0.00002456097],"domain_scores_gemma":[0.999525,0.0001207176,0.0001857988,0.0000259761,0.00008520606,0.00005738277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006676993,0.00007677809,0.9863564,0.00002632766,0.00007578271,0.0001430252,0.00004494291,0.0001456342,0.001932883,0.00001900427,0.00009629808,0.01041523],"study_design_scores_gemma":[0.00002679827,0.0003896819,0.9958877,0.00001271618,0.00008627101,0.001089369,0.00008765264,0.0008987447,0.001121454,0.00007011168,0.0003228381,0.000006672425],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970447,0.001259306,0.0003330481,0.00003174897,0.000005898374,0.00001498183,0.0001770495,0.000009372831,0.001123738],"genre_scores_gemma":[0.9992163,0.0001950634,0.0003143896,0.00001577567,0.000008178874,0.00001044904,0.0001041661,0.000001103157,0.0001344677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001392928,"threshold_uncertainty_score":0.004339933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1045349915681722,"score_gpt":0.4238400323027157,"score_spread":0.3193050407345435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}