{"id":"W4378515347","doi":"10.3390/medicina59050945","title":"The Use of F-18 FDG PET-Based Cognitive Reserve to Evaluate Cognitive Decline in Alzheimer’s Disease, Independent of Educational Influence","year":2023,"lang":"en","type":"article","venue":"Medicina","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Cognitive reserve; Clinical Dementia Rating; Dementia; Cognition; Standardized uptake value; Psychology; Demographics; Cognitive decline; Positron emission tomography; Alzheimer's disease; Mini–Mental State Examination; Medicine; Disease; Internal medicine; Audiology; Neuroscience; Cognitive impairment; Demography","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.001510168,0.0001718111,0.0003337796,0.0004735387,0.00008766317,0.00001515067,0.0001802045,0.00003667616,0.000575887],"category_scores_gemma":[0.009999054,0.0001222479,0.00009369425,0.001200385,0.0004506092,0.00009856559,0.0001821798,0.0002560925,0.0001129967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006324974,"about_ca_system_score_gemma":0.001656347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001530662,"about_ca_topic_score_gemma":0.0009647986,"domain_scores_codex":[0.996759,0.0003125879,0.0005620671,0.0003412944,0.001602044,0.000423026],"domain_scores_gemma":[0.9941121,0.003638932,0.0001567006,0.0002448038,0.001500766,0.0003467008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004437356,0.0006148808,0.9816055,0.0001239328,0.0002216372,0.0001373731,0.000435379,0.00005459685,0.0004257956,0.00004173667,0.001859434,0.0100424],"study_design_scores_gemma":[0.004174491,0.0008988071,0.9870737,0.001581282,0.0003867926,0.000004135478,0.001173429,0.001001028,0.002986618,0.0002012183,0.0004099553,0.0001085879],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840353,0.0004580583,0.00004046711,0.0130561,0.00008251557,0.001592059,0.0001151858,0.00001535209,0.0006049916],"genre_scores_gemma":[0.9973648,0.0001108734,0.00003156703,0.001267642,0.0000564883,0.0002443495,0.0002094547,0.00002114947,0.0006936446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01332956,"threshold_uncertainty_score":0.9983401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1045349915681722,"score_gpt":0.4238400323027157,"score_spread":0.3193050407345435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}