{"id":"W4378515762","doi":"10.3390/molecules28104022","title":"Preclinical Evaluation of a PSMA-Targeting Homodimer with an Optimized Linker for Imaging of Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"Molecules","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"TRIUMF","funders":"","keywords":"Biodistribution; Linker; Internalization; Prostate cancer; Chemistry; Glutamate carboxypeptidase II; Cancer research; DOTA; In vivo; Radionuclide therapy; Cancer; Biophysics; In vitro; Chelation; Biochemistry; Medicine; Nuclear medicine; Receptor; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004076897,0.0004258998,0.000328897,0.0002164179,0.0001067482,0.0002204131,0.000314316,0.0003487042,0.000830931],"category_scores_gemma":[0.000140303,0.0001824037,0.0002043192,0.0002214153,0.0001564453,0.0001961553,0.0001062761,0.0005192526,0.0002243552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003389074,"about_ca_system_score_gemma":0.0002927777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007977844,"about_ca_topic_score_gemma":0.0009782764,"domain_scores_codex":[0.9998736,0.00002838232,0.000006682011,0.00002508464,0.00003356383,0.00003261269],"domain_scores_gemma":[0.99991,0.000012162,0.00002129154,0.000009486997,0.00001382425,0.0000331616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001756573,0.0004218566,0.00007631358,0.00004106825,0.00001336837,0.00001658599,0.00002323908,0.0005938736,0.9970127,0.00003995391,0.00006221368,0.001523212],"study_design_scores_gemma":[0.00008720501,0.006683359,0.001407341,0.000004826532,0.00004811878,0.00009677924,0.00001590803,0.003057884,0.9869221,0.00001668343,0.001651627,0.000008163581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962763,0.0008919934,0.00188291,0.00005770195,0.00002257556,0.0001089941,0.0001721414,0.00006062033,0.0005268993],"genre_scores_gemma":[0.9932145,0.0009246195,0.003909861,0.00003962317,0.000008735573,0.00008805368,0.0003379367,0.00002010273,0.001456557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000830931,"threshold_uncertainty_score":0.002779722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08820287676201533,"score_gpt":0.4379384843395997,"score_spread":0.3497356075775844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}