{"id":"W4378515762","doi":"10.3390/molecules28104022","title":"Preclinical Evaluation of a PSMA-Targeting Homodimer with an Optimized Linker for Imaging of Prostate Cancer","year":2023,"lang":"en","type":"article","venue":"Molecules","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"TRIUMF","funders":"","keywords":"Biodistribution; Linker; Internalization; Prostate cancer; Chemistry; Glutamate carboxypeptidase II; Cancer research; DOTA; In vivo; Radionuclide therapy; Cancer; Biophysics; In vitro; Chelation; Biochemistry; Medicine; Nuclear medicine; Receptor; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008031048,0.00008734115,0.0002323551,0.0001037224,0.00003622348,0.00000656938,0.00004774149,0.00003248203,0.00003709298],"category_scores_gemma":[0.0001494341,0.00005892714,0.00006205733,0.0002147591,0.0001019035,0.00005519207,0.00002177719,0.00006993293,0.000001389695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000411545,"about_ca_system_score_gemma":0.0003627099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007819045,"about_ca_topic_score_gemma":0.000007767114,"domain_scores_codex":[0.9988582,0.00007267702,0.0002372069,0.0002071848,0.0004253978,0.0001993212],"domain_scores_gemma":[0.998955,0.00007870917,0.0001034411,0.0001534628,0.0006465904,0.00006286502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.03197473,0.00158753,0.4393722,0.002855961,0.001549041,0.000069733,0.008687009,0.02710386,0.2572046,0.0001151489,0.003647309,0.2258329],"study_design_scores_gemma":[0.03316101,0.002299042,0.07798138,0.0009643243,0.001455454,0.00000483526,0.001368211,0.5912221,0.2902249,0.0006907595,0.0003113275,0.0003166952],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955509,0.001598522,0.000274816,0.000889211,0.00003932079,0.001384126,0.00004945247,0.00003554624,0.0001781548],"genre_scores_gemma":[0.9928385,0.0001748694,0.005900247,0.00002981966,0.00004532926,0.0004997666,0.0001986694,0.00002754297,0.0002852259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5641182,"threshold_uncertainty_score":0.2402979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08820287676201533,"score_gpt":0.4379384843395997,"score_spread":0.3497356075775844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}