{"id":"W4378528003","doi":"10.3390/cancers15112938","title":"Mutation in the Common Docking Domain Affects MAP Kinase ERK2 Catalysis and Stability","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ministero dell’Istruzione, dell’Università e della Ricerca; Ontario Genomics; Genome Canada; McGill University; Genentech; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"MAPK/ERK pathway; Phosphorylation; Signal transduction; Kinase; Cell biology; Mutant; Effector; Docking (animal); Chemistry; Protein kinase A; Biology; Missense mutation; Mutation; Biochemistry; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001168053,0.0004665747,0.000286431,0.0001577907,0.0001486079,0.0001950354,0.0002761653,0.0003232075,0.001015022],"category_scores_gemma":[0.0002666833,0.0001398485,0.0003894022,0.000190609,0.0002742459,0.000154817,0.0002271865,0.0003623342,0.0002808705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002508096,"about_ca_system_score_gemma":0.0001347993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007177821,"about_ca_topic_score_gemma":0.0005065657,"domain_scores_codex":[0.9998442,0.00003449915,0.00002351537,0.00003602983,0.00003535051,0.00002643049],"domain_scores_gemma":[0.9998208,0.00004283479,0.0000572255,0.00001822699,0.00001670183,0.00004425057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000429027,0.00007132313,0.0008217118,0.00003075423,0.00003001669,0.000310145,0.0000225758,0.0003428964,0.996501,0.0001072367,0.00003572974,0.001297547],"study_design_scores_gemma":[0.000064138,0.0005865134,0.01329444,0.00001145922,0.00007601859,0.00266059,0.00006455928,0.003957377,0.9774787,0.0001146098,0.001662234,0.00002952125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989297,0.0001616277,0.0005561245,0.00001677102,0.00001065087,0.000006899215,0.0001059739,0.0000143052,0.0001980321],"genre_scores_gemma":[0.9990896,0.00008133485,0.0003846197,0.00001481463,0.000003264271,0.000005181099,0.0001461887,0.00001310338,0.0002619278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001015022,"threshold_uncertainty_score":0.003395557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01404174596594583,"score_gpt":0.2550226126815541,"score_spread":0.2409808667156083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}