{"id":"W4378528831","doi":"10.1016/j.hrthm.2023.05.027","title":"Reclassifying variants in genes associated with arrhythmogenic cardiomyopathies","year":2023,"lang":"en","type":"letter","venue":"Heart Rhythm","topic":"Cardiovascular Effects of Exercise","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Pharmacogenomics; Cardiomyopathy; Genetic testing; Dilated cardiomyopathy; Filamin; Bioinformatics; Genetics; Heart failure; Internal medicine; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001120537,0.0006578762,0.001059155,0.0006582692,0.001753494,0.00131084,0.0008775435,0.02185774,0.002961987],"category_scores_gemma":[0.009186156,0.0003228906,0.0008266668,0.0005940778,0.00106494,0.0007529526,0.0004693866,0.008778544,0.001982802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001462939,"about_ca_system_score_gemma":0.001221732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005351346,"about_ca_topic_score_gemma":0.008369171,"domain_scores_codex":[0.9989221,0.0002655259,0.0002000671,0.0001789651,0.0002290335,0.0002043238],"domain_scores_gemma":[0.9967907,0.001822799,0.0002155368,0.0001360509,0.0004663319,0.0005685855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0006118047,0.0003600809,0.04294199,0.0001644759,0.0001718193,0.181066,0.000797114,0.0005258133,0.003461612,0.005220751,0.7137722,0.05090637],"study_design_scores_gemma":[0.001514854,0.001000635,0.0772991,0.001491092,0.0007267717,0.2638461,0.00279949,0.01048302,0.003326172,0.03640493,0.6008392,0.0002686297],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.0291137,0.00256059,0.00077193,0.9242103,0.02598389,0.00007196121,0.0003446063,0.0001132085,0.0168299],"genre_scores_gemma":[0.1797743,0.003012608,0.002015725,0.6770623,0.1216715,0.0001038109,0.0002911618,0.0001203021,0.01594824],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02185774,"threshold_uncertainty_score":0.01064038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02652253074666889,"score_gpt":0.2581530378249375,"score_spread":0.2316305070782687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}