{"id":"W4378575099","doi":"10.1186/s13063-023-07379-w","title":"Hyperhydration to Improve Kidney Outcomes in Children with Shiga Toxin-Producing E. coli Infection: a multinational embedded cluster crossover randomized trial (the HIKO STEC trial)","year":2023,"lang":"en","type":"article","venue":"Trials","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Maternal and Child Health Bureau; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Health Resources and Services Administration; Children's Hospital Foundation; National Institutes of Health; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; Alberta Children's Hospital Foundation","keywords":"Medicine; Randomized controlled trial; Dialysis; Observational study; Intensive care medicine; Adverse effect; Renal replacement therapy; Internal medicine; Acute kidney injury; Pediatrics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003497118,0.001512533,0.002977377,0.0004301798,0.0004788703,0.001055796,0.0008639766,0.001744771,0.003801057],"category_scores_gemma":[0.003998088,0.0005829426,0.002707667,0.0004439176,0.001351571,0.00109711,0.0008467513,0.002284809,0.0003157965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001041262,"about_ca_system_score_gemma":0.001802838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001814701,"about_ca_topic_score_gemma":0.002432857,"domain_scores_codex":[0.9979343,0.001426609,0.0001130648,0.0002430876,0.00009527204,0.0001876412],"domain_scores_gemma":[0.9977496,0.0007607062,0.0006492328,0.0002181146,0.0001266274,0.0004957379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9825064,0.005399167,0.001121456,0.0007886355,0.00136514,0.00002733931,0.00005858415,0.000471901,0.0006977089,0.0001118946,0.0003372172,0.007114554],"study_design_scores_gemma":[0.9595886,0.03741659,0.001662368,0.00005525793,0.0005278975,0.00001847812,0.000020857,0.0003557515,0.000118531,0.00009493917,0.0001318184,0.000008855885],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929407,0.002724745,0.0004337875,0.0004800585,0.0002446687,0.002233713,0.0003357225,0.0000513466,0.0005553213],"genre_scores_gemma":[0.990006,0.001379778,0.002548121,0.0006843703,0.0002560282,0.004007387,0.0003974999,0.00001631151,0.0007045942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003801057,"threshold_uncertainty_score":0.01849478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03668295177014925,"score_gpt":0.3653734054855213,"score_spread":0.328690453715372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}