{"id":"W4378575099","doi":"10.1186/s13063-023-07379-w","title":"Hyperhydration to Improve Kidney Outcomes in Children with Shiga Toxin-Producing E. coli Infection: a multinational embedded cluster crossover randomized trial (the HIKO STEC trial)","year":2023,"lang":"en","type":"article","venue":"Trials","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Maternal and Child Health Bureau; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Health Resources and Services Administration; Children's Hospital Foundation; National Institutes of Health; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; Alberta Children's Hospital Foundation","keywords":"Medicine; Randomized controlled trial; Dialysis; Observational study; Intensive care medicine; Adverse effect; Renal replacement therapy; Internal medicine; Acute kidney injury; Pediatrics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.007762873,0.0002536595,0.000899087,0.0001576093,0.0002197821,0.0001393685,0.0001976856,0.0001474025,0.00003092176],"category_scores_gemma":[0.02703145,0.0001568798,0.0002747601,0.000476622,0.0001265053,0.00001671238,0.0002365184,0.0001735387,0.00003166329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007656871,"about_ca_system_score_gemma":0.0003280802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002800883,"about_ca_topic_score_gemma":0.0003216856,"domain_scores_codex":[0.9962528,0.001478634,0.0008473726,0.0005726484,0.0004677709,0.0003807116],"domain_scores_gemma":[0.9981501,0.0007908813,0.0002960007,0.0004478986,0.0002027984,0.0001123923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9581725,0.0001666343,0.001955802,0.00001121585,0.0006070808,8.213417e-7,0.0003026585,0.0003872518,0.03490435,0.00004724437,0.003047053,0.0003973738],"study_design_scores_gemma":[0.9795986,0.0008860971,0.005029813,0.00001693244,0.00009062617,0.000001251488,0.00004162871,0.0002116245,0.01255726,0.00006774047,0.001247335,0.0002510478],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984078,0.00003057419,0.000192144,0.002753404,0.0006419173,0.01205663,0.00004824569,0.00004428563,0.0001547968],"genre_scores_gemma":[0.9883067,0.00006503639,0.0003051906,0.001043212,0.001787909,0.004966647,0.0001770889,0.00004038537,0.003307852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0223471,"threshold_uncertainty_score":0.9811643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03668295177014925,"score_gpt":0.3653734054855213,"score_spread":0.328690453715372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}