{"id":"W4378611084","doi":"10.1101/2023.05.27.542563","title":"Sequential Switching Through IgG1 is Redundant for Allergic Reactivity and Memory to Allergens","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Allergic Rhinitis and Sensitization","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"University of Illinois at Urbana-Champaign; McMaster University","keywords":"Immunoglobulin E; Immunoglobulin class switching; Immunology; Allergen; Isotype; Antibody; Sensitization; Allergy; Biology; B cell; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003370627,0.0003178498,0.0002775225,0.0003448399,0.0001701413,0.000431706,0.0002938778,0.0003439262,0.002436345],"category_scores_gemma":[0.0002495071,0.0001554102,0.0002423058,0.0001681171,0.000299792,0.0002864556,0.0002519029,0.0005576998,0.000517233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003635682,"about_ca_system_score_gemma":0.0002293558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005976511,"about_ca_topic_score_gemma":0.0003772085,"domain_scores_codex":[0.999795,0.00002923788,0.00001308708,0.00005112909,0.00005231059,0.00005923588],"domain_scores_gemma":[0.9998168,0.00004017541,0.00005208364,0.00003996614,0.00002104225,0.00002981932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002632139,0.00004454355,0.001808827,0.00005713546,0.00001728013,0.0002228216,0.00002654817,0.0002182418,0.9914072,0.001085001,0.0001619379,0.00468732],"study_design_scores_gemma":[0.00006513991,0.0002306503,0.02095877,0.00001413433,0.00004617279,0.00144817,0.00005347329,0.003696088,0.9667853,0.001093565,0.005599681,0.000008790727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920839,0.001095383,0.003165266,0.0001652233,0.00003216953,0.00001047153,0.000185691,0.0001072844,0.003154669],"genre_scores_gemma":[0.9963356,0.0001930062,0.001445119,0.0000588579,0.00001740603,0.000006836754,0.000229814,0.00001894081,0.001694247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002436345,"threshold_uncertainty_score":0.008150339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.042810162944116,"score_gpt":0.27710030300405,"score_spread":0.234290140059934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}