{"id":"W4378611084","doi":"10.1101/2023.05.27.542563","title":"Sequential Switching Through IgG1 is Redundant for Allergic Reactivity and Memory to Allergens","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Allergic Rhinitis and Sensitization","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"University of Illinois at Urbana-Champaign; McMaster University","keywords":"Immunoglobulin E; Immunoglobulin class switching; Immunology; Allergen; Isotype; Antibody; Sensitization; Allergy; Biology; B cell; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007213302,0.0006468392,0.0009845792,0.0002636212,0.0003122702,0.0001834965,0.000215636,0.0006422629,0.00004173355],"category_scores_gemma":[0.0004161823,0.0006821024,0.0002625333,0.0003417322,0.00007249381,0.0001702861,0.0005199993,0.0007079904,0.00005929564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003122906,"about_ca_system_score_gemma":0.0006321992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004173123,"about_ca_topic_score_gemma":0.00002864398,"domain_scores_codex":[0.9965087,0.00009657843,0.0007020546,0.001475959,0.0005390383,0.0006776541],"domain_scores_gemma":[0.9972987,0.0001184115,0.0003766938,0.00114184,0.0006283853,0.0004359526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004864693,0.0002292688,0.0007006207,0.001251618,0.0009509272,0.0003784665,0.0006300618,0.0001386631,0.983787,0.0007394298,0.01068925,0.00001822291],"study_design_scores_gemma":[0.009276833,0.001289013,0.1774364,0.006504735,0.00211881,0.000002452631,0.0002476594,0.01338537,0.6688504,0.0001869937,0.1148623,0.00583901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707801,0.0004480418,0.0188907,0.004364725,0.002117843,0.002405879,0.0003075343,0.0006407535,0.00004442546],"genre_scores_gemma":[0.9805817,0.001049435,0.01481427,0.001575714,0.001306924,0.0002760148,0.000003947368,0.0002882326,0.0001037643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3149366,"threshold_uncertainty_score":0.999563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.042810162944116,"score_gpt":0.27710030300405,"score_spread":0.234290140059934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}