{"id":"W4378635638","doi":"10.14785/lymphosign-2023-0005","title":"Management of newborn screening for severe combined immunodeficiency at a quaternary referral centre—an updated algorithm","year":2023,"lang":"en","type":"article","venue":"LymphoSign Journal","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Referral; Pediatrics; Severe combined immunodeficiency; Newborn screening; Medicine; Intervention (counseling); Algorithm; Family medicine; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000755206,0.000305494,0.0004264489,0.0002791779,0.0008781876,0.00004217936,0.0006925268,0.0002092449,0.0005412356],"category_scores_gemma":[0.000009769545,0.000277656,0.0002829261,0.0004736501,0.0001764481,0.0002559696,0.0002167419,0.0002389033,0.000206787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001098722,"about_ca_system_score_gemma":0.00006995782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007468698,"about_ca_topic_score_gemma":8.244983e-7,"domain_scores_codex":[0.9977263,0.0001850074,0.0007535132,0.0003612444,0.0001108201,0.0008630991],"domain_scores_gemma":[0.9989657,0.00005365278,0.0004029388,0.0004061775,0.0001470751,0.00002440707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003094877,0.001006316,0.001035394,0.00009721526,0.001586527,0.0001283188,0.004130105,0.0009622082,0.2096097,0.001531235,0.00962281,0.7671953],"study_design_scores_gemma":[0.1137235,0.007815927,0.07890332,0.002212106,0.001901936,0.006232914,0.06405339,0.0349035,0.1326527,0.01090145,0.5410135,0.005685814],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9352381,0.01193559,0.04635882,0.0005323563,0.003089687,0.0009528229,0.0001969289,0.000374206,0.001321514],"genre_scores_gemma":[0.9821866,0.0005677232,0.004669265,0.0001374689,0.0000159431,0.00003052271,0.001507613,0.00008180112,0.01080303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7615095,"threshold_uncertainty_score":0.9999676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02011854609327672,"score_gpt":0.2572969888797207,"score_spread":0.237178442786444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}