{"id":"W4378635638","doi":"10.14785/lymphosign-2023-0005","title":"Management of newborn screening for severe combined immunodeficiency at a quaternary referral centre—an updated algorithm","year":2023,"lang":"en","type":"article","venue":"LymphoSign Journal","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Referral; Pediatrics; Severe combined immunodeficiency; Newborn screening; Medicine; Intervention (counseling); Algorithm; Family medicine; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002748273,0.001221493,0.0009969738,0.004195603,0.001293006,0.002353942,0.002473766,0.001719295,0.008738612],"category_scores_gemma":[0.01064206,0.000396644,0.001420121,0.001569455,0.0005343584,0.002387209,0.002368646,0.002808056,0.002938536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003985004,"about_ca_system_score_gemma":0.005682196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02006482,"about_ca_topic_score_gemma":0.02594972,"domain_scores_codex":[0.9970309,0.0007044293,0.0008389857,0.0002825393,0.0008104044,0.0003328419],"domain_scores_gemma":[0.9949644,0.0007882495,0.0006285753,0.0001031922,0.002748079,0.0007675897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001694974,0.0005122207,0.06532624,0.0009445273,0.0001316732,0.003820716,0.0006984046,0.005640644,0.001017324,0.007026867,0.3964781,0.5182338],"study_design_scores_gemma":[0.000413625,0.000624747,0.1294504,0.02009345,0.0005567377,0.03232462,0.002161572,0.02653345,0.003207491,0.01872763,0.7655587,0.000347604],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"methods","genre_scores_codex":[0.08225711,0.1178742,0.2197648,0.2292649,0.009949251,0.01667488,0.01630578,0.008804439,0.2991047],"genre_scores_gemma":[0.2000145,0.08529931,0.6119671,0.03756115,0.004186145,0.007549753,0.02471361,0.0009444638,0.02776403],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.02006482,"threshold_uncertainty_score":0.03989607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02011854609327672,"score_gpt":0.2572969888797207,"score_spread":0.237178442786444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}