{"id":"W4378640017","doi":"10.1080/15592294.2023.2216005","title":"The UHRF1 protein is a key regulator of retrotransposable elements and innate immune response to viral RNA in human cells","year":2023,"lang":"en","type":"article","venue":"Epigenetics","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"National Institute of General Medical Sciences; National Cancer Institute; Medical Research Council; National Institutes of Health; Royal Society","keywords":"Biology; DNA methylation; Epigenetics; Chromatin; Histone; Innate immune system; Cell biology; RNA interference; Gene silencing; Regulation of gene expression; Genetics; RNA; Gene; Molecular biology; Gene expression; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004544109,0.00008494379,0.0001115948,0.00001823899,0.0001992503,0.00002962088,0.0001838336,0.00005211383,0.00006366907],"category_scores_gemma":[0.00003597332,0.00003507567,0.00003499138,0.0004762535,0.00004797627,0.00001602053,0.00008209819,0.00005827488,0.0000180286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001221731,"about_ca_system_score_gemma":0.000009097058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000158126,"about_ca_topic_score_gemma":0.0004405225,"domain_scores_codex":[0.9990357,0.0001018582,0.0002963482,0.0001727248,0.0001645081,0.0002289287],"domain_scores_gemma":[0.9996779,0.00008124457,0.00006054299,0.00008559132,0.00003857113,0.00005616371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006579285,0.00002276072,0.001904316,0.000003798289,0.000005340452,0.000001028874,0.0003856428,0.00001726441,0.9945123,0.00009586822,0.00006955084,0.002916338],"study_design_scores_gemma":[0.0001667866,0.000397461,0.4829091,0.00002631966,0.000003806802,1.744065e-7,0.0001108029,0.00007014143,0.504788,0.001825356,0.009609134,0.00009290953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961167,0.0001103674,6.057006e-7,0.003178783,0.00003984327,0.0004068414,0.00006431586,0.00001593364,0.00006662134],"genre_scores_gemma":[0.9977044,0.0000583849,0.0001627298,0.00004060647,0.00003258006,0.00003284255,0.000008372296,0.000001276303,0.001958736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4897243,"threshold_uncertainty_score":0.1532492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0137606959171361,"score_gpt":0.2333672387404891,"score_spread":0.219606542823353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}