{"id":"W4378640017","doi":"10.1080/15592294.2023.2216005","title":"The UHRF1 protein is a key regulator of retrotransposable elements and innate immune response to viral RNA in human cells","year":2023,"lang":"en","type":"article","venue":"Epigenetics","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"National Institute of General Medical Sciences; National Cancer Institute; Medical Research Council; National Institutes of Health; Royal Society","keywords":"Biology; DNA methylation; Epigenetics; Chromatin; Histone; Innate immune system; Cell biology; RNA interference; Gene silencing; Regulation of gene expression; Genetics; RNA; Gene; Molecular biology; Gene expression; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001362435,0.0002760679,0.0001859575,0.000194101,0.000195368,0.0002876903,0.0001544604,0.0002076945,0.00118168],"category_scores_gemma":[0.0001289458,0.00009068774,0.0001647539,0.0001627366,0.0002307336,0.000128978,0.0002118601,0.0002442999,0.0006226497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003168946,"about_ca_system_score_gemma":0.0001468833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005989724,"about_ca_topic_score_gemma":0.0005545584,"domain_scores_codex":[0.9998493,0.00001522172,0.00000843949,0.00006252518,0.00004256225,0.00002191861],"domain_scores_gemma":[0.9999266,0.000006667424,0.00003480302,0.000007984795,0.00000829276,0.00001562878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005429917,0.000004431226,0.0007222557,0.00003506066,0.000005263085,0.00005577615,0.0000119869,0.00005429897,0.9938313,0.0002055975,0.0001115233,0.004908325],"study_design_scores_gemma":[0.00000971726,0.0002090648,0.0275305,0.00001303499,0.00002237733,0.001091616,0.00004026071,0.0009300162,0.9532353,0.0003547188,0.01655143,0.00001184364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.929059,0.02815119,0.03197882,0.0004828918,0.0001407829,0.00006335552,0.002569326,0.0007443206,0.006810416],"genre_scores_gemma":[0.9877936,0.00264307,0.004029146,0.00006562456,0.00003081199,0.00002189359,0.001037074,0.00003376868,0.004344875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00118168,"threshold_uncertainty_score":0.003953159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0137606959171361,"score_gpt":0.2333672387404891,"score_spread":0.219606542823353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}