{"id":"W4378640462","doi":"10.1002/ejhf.2920","title":"Safety, Tolerability and Efficacy of Up-Titration of Guideline-Directed Medical Therapies for Acute Heart Failure in Elderly Patients: A Sub-Analysis of the STRONG-HF Randomized Clinical Trial","year":2023,"lang":"en","type":"article","venue":"European Journal of Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"","keywords":"Medicine; Hazard ratio; Clinical endpoint; Confidence interval; Randomized controlled trial; Heart failure; Tolerability; Internal medicine; Guideline; Clinical trial; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007355823,0.001445652,0.003164178,0.0003049062,0.0002887509,0.001033287,0.0006770907,0.001392661,0.003075944],"category_scores_gemma":[0.006123803,0.0004292381,0.004321057,0.0003473586,0.0008583716,0.0009527172,0.0006430026,0.001908015,0.0003252665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007200224,"about_ca_system_score_gemma":0.0007706298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006825976,"about_ca_topic_score_gemma":0.001474151,"domain_scores_codex":[0.9960425,0.002986378,0.0002465355,0.0003318897,0.000160768,0.0002320015],"domain_scores_gemma":[0.9948772,0.002091805,0.001417416,0.0005534685,0.0002946295,0.000765656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9757482,0.002149085,0.005095102,0.0005652361,0.005678119,0.0000205155,0.00003121916,0.0003641519,0.0006080695,0.00008563996,0.0005940547,0.009060547],"study_design_scores_gemma":[0.8765164,0.08428259,0.02960489,0.0001169211,0.007093017,0.00005094704,0.00004902286,0.001037643,0.0003430999,0.0003061559,0.0005632016,0.00003606204],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923178,0.004218963,0.0003910589,0.0003889331,0.0002145336,0.0007671368,0.0006985533,0.0000311245,0.0009719071],"genre_scores_gemma":[0.9948801,0.0009375371,0.0008397506,0.0006946073,0.0004839393,0.0008230067,0.0009041296,0.000008182319,0.0004289055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007355823,"threshold_uncertainty_score":0.03890181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0285617838059282,"score_gpt":0.3454305386261302,"score_spread":0.316868754820202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}