{"id":"W4378648884","doi":"10.1152/physiol.2023.38.s1.5732496","title":"Impaired mitochondrial quality control in skeletal muscles from C57 and D2 mdx model of Duchenne Muscular Dystrophy","year":2023,"lang":"en","type":"article","venue":"Physiology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"","keywords":"Duchenne muscular dystrophy; Mitochondrial fission; Mitophagy; FIS1; MFN2; Skeletal muscle; mdx mouse; DNM1L; Muscular dystrophy; Biology; mitochondrial fusion; PINK1; Endocrinology; Mitochondrion; Internal medicine; Dystrophin; Medicine; Cell biology; Mitochondrial DNA; Autophagy; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002679875,0.0006429906,0.0006913112,0.001040286,0.0003415669,0.0003275019,0.0003328085,0.0006349806,0.002323096],"category_scores_gemma":[0.0001739031,0.0003143897,0.0004781833,0.000382013,0.0004606569,0.0004244267,0.0003516954,0.001237051,0.0003039368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005006631,"about_ca_system_score_gemma":0.0002976859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001715837,"about_ca_topic_score_gemma":0.002817996,"domain_scores_codex":[0.9995541,0.0000374319,0.00006855847,0.0001355493,0.000108597,0.00009588115],"domain_scores_gemma":[0.9996485,0.0000275211,0.0001052944,0.00002077798,0.00003067186,0.0001672376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001993485,0.0006165965,0.001580478,0.0001020011,0.00002288254,0.0003009824,0.00007488158,0.00008281335,0.9938495,0.00006828939,0.0001190646,0.00118908],"study_design_scores_gemma":[0.000470305,0.01433303,0.1690655,0.00009716071,0.0002232465,0.002063851,0.0006928106,0.002485404,0.8075475,0.0002265112,0.002728241,0.00006651895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974828,0.0007670217,0.0004544442,0.0001113171,0.00004437875,0.00003254085,0.0005543203,0.00002849877,0.0005248017],"genre_scores_gemma":[0.9891955,0.001026339,0.001409078,0.0001925878,0.00002167361,0.0002407005,0.001342837,0.00002453027,0.006546696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002323096,"threshold_uncertainty_score":0.007771492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907352224714218,"score_gpt":0.2627181930751741,"score_spread":0.2436446708280319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}