{"id":"W4378648884","doi":"10.1152/physiol.2023.38.s1.5732496","title":"Impaired mitochondrial quality control in skeletal muscles from C57 and D2 mdx model of Duchenne Muscular Dystrophy","year":2023,"lang":"en","type":"article","venue":"Physiology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"","keywords":"Duchenne muscular dystrophy; Mitochondrial fission; Mitophagy; FIS1; MFN2; Skeletal muscle; mdx mouse; DNM1L; Muscular dystrophy; Biology; mitochondrial fusion; PINK1; Endocrinology; Mitochondrion; Internal medicine; Dystrophin; Medicine; Cell biology; Mitochondrial DNA; Autophagy; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001355505,0.0001763914,0.0004078849,0.00008052379,0.00003643725,0.000005005806,0.0001375781,0.0002826531,0.00002390663],"category_scores_gemma":[0.0001910651,0.0001673262,0.0001354237,0.0001080746,0.0001618517,0.000004819061,0.00008458854,0.0001192619,0.00001323519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007118706,"about_ca_system_score_gemma":0.00004728763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002093098,"about_ca_topic_score_gemma":0.00009210476,"domain_scores_codex":[0.9984959,0.0002915514,0.0003585179,0.0004941531,0.00007731711,0.000282571],"domain_scores_gemma":[0.9993325,0.00006649487,0.0001197092,0.000352868,0.00005684833,0.00007158142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004958272,0.00006112499,0.0003871001,0.00001415558,0.00004450768,0.00000261909,0.00007644909,0.001231116,0.996272,0.0002571422,0.0004999452,0.0006579859],"study_design_scores_gemma":[0.03464133,0.004352902,0.4603333,0.00007853437,0.0002564385,0.00002244727,0.0007080592,0.05505625,0.3899091,0.04195562,0.0103129,0.002373086],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970724,0.0001429121,0.001703468,0.0001649765,0.0004556345,0.0002140922,0.0001746398,0.00002343613,0.00004842753],"genre_scores_gemma":[0.9979528,0.0001186256,0.0006920961,0.0002784285,0.0004394444,0.00003422595,0.0004012588,0.0000157462,0.00006738285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6063629,"threshold_uncertainty_score":0.6823363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907352224714218,"score_gpt":0.2627181930751741,"score_spread":0.2436446708280319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}