{"id":"W4378648987","doi":"10.1152/physiol.2023.38.s1.5733733","title":"Decreased arterial elastance following a novel RSK3/mAKAPß gene therapy is associated with improved bradykinin-dependent pial artery dilation in aortic-banded, Western diet-fed female Ossabaw swine","year":2023,"lang":"en","type":"article","venue":"Physiology","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Internal medicine; Medicine; Cardiology; Heart failure; Bradykinin; Stroke volume; Cardiac function curve; Blood pressure; Hemodynamics; Ejection fraction; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002667809,0.0003045156,0.0008034678,0.0001665327,0.0001049409,0.0000302965,0.00009432779,0.0002160804,0.00002303436],"category_scores_gemma":[0.00007704904,0.0002424697,0.0002628867,0.0003957719,0.00005969202,0.0001190489,0.00005121597,0.0002530647,0.00002037738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001268348,"about_ca_system_score_gemma":0.0001339151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001317403,"about_ca_topic_score_gemma":0.0001281991,"domain_scores_codex":[0.9979621,0.00008390434,0.0004937419,0.0006018985,0.000289904,0.000568426],"domain_scores_gemma":[0.9990904,0.0001533853,0.000193544,0.0003531139,0.00008514395,0.0001243907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004963069,0.0002384633,0.01667861,0.00001743042,0.0003197348,0.00001931144,0.0008118543,0.0001907025,0.9761292,0.000001982597,0.00001973379,0.0006099369],"study_design_scores_gemma":[0.01856857,0.001418416,0.9365606,0.0002458935,0.0001406625,0.0000164772,0.0001737789,0.0190891,0.02323226,0.0000708873,0.00004989522,0.0004334413],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976974,0.00007943859,0.0004642741,0.0002672781,0.0006362525,0.0006248289,0.00004346221,0.0001547344,0.00003238043],"genre_scores_gemma":[0.9981654,0.00006519735,0.0001067647,0.0004565764,0.000575865,0.00007695379,0.0003628306,0.0000661376,0.0001242373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9528969,"threshold_uncertainty_score":0.9887629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02639618833594636,"score_gpt":0.2771738992848511,"score_spread":0.2507777109489047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}