{"id":"W4378650693","doi":"10.1186/s13223-023-00795-2","title":"A multicenter chart review of patient characteristics, treatment, and outcomes in hereditary angioedema: unmet need for more effective long-term prophylaxis","year":2023,"lang":"en","type":"article","venue":"Allergy Asthma and Clinical Immunology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McMaster University","funders":"CVS Health; Pearl Therapeutics; Mylan; BioCryst; Takeda Development Center Americas; CSL Behring; Sanofi; Takeda Pharmaceuticals International; AstraZeneca; Pfizer","keywords":"Medicine; Hereditary angioedema; Icatibant; Danazol; Poisson regression; Angioedema; Cohort; Retrospective cohort study; Internal medicine; Pediatrics; Endometriosis; Immunology; Population","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002680019,0.0001450375,0.0003199803,0.002813092,0.0004594445,0.0007195831,0.0004110232,0.0002746107,0.001540697],"category_scores_gemma":[0.008982338,0.000197317,0.0003986425,0.004253858,0.0002711065,0.000655325,0.0005189013,0.0002717755,0.0001801686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001216603,"about_ca_system_score_gemma":0.001815038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01269306,"about_ca_topic_score_gemma":0.01641215,"domain_scores_codex":[0.9975007,0.0007675704,0.0007383581,0.0004130095,0.0004106287,0.0001697569],"domain_scores_gemma":[0.9754321,0.004467906,0.01555194,0.0007233784,0.00287276,0.0009518947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003373284,0.00002492519,0.994919,0.0001131338,0.0000326566,0.0001753573,0.0001978662,0.00003980117,0.00007083893,0.00003418358,0.001109286,0.00324919],"study_design_scores_gemma":[0.000008958025,0.00004847316,0.996959,0.0001314601,0.00003008059,0.0004587657,0.0006699137,0.0001725155,0.00008433818,0.00001303169,0.001417211,0.000006293508],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844809,0.003561614,0.0003604083,0.0003808461,0.00002790224,0.0002133856,0.00912543,0.00003196842,0.001817575],"genre_scores_gemma":[0.9937068,0.001265885,0.0007228939,0.000145641,0.00002828479,0.0001156692,0.003844953,0.000006363831,0.0001634727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01269306,"threshold_uncertainty_score":0.02523834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01789365884470319,"score_gpt":0.3359164575740713,"score_spread":0.3180227987293682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}