{"id":"W4378713804","doi":"10.1038/s41591-023-02380-x","title":"Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease","year":2023,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":310,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Montreal Neurological Institute and Hospital; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; HORIZON EUROPE Framework Programme; National Institutes of Health; Olav Thon Stiftelsen; National Heart, Lung, and Blood Institute; UK Dementia Research Institute; Vetenskapsrådet; Hjärnfonden; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; EU Joint Programme – Neurodegenerative Disease Research; European Commission; Stiftelsen för Gamla Tjänarinnor; Familjen Erling-Perssons Stiftelse; BrightFocus Foundation; National Institute on Aging; Alzheimer's Association; Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; Alzheimerfonden; Weston Brain Institute; Alzheimer's Drug Discovery Foundation","keywords":"Astrocyte; Pathological; Pathophysiology; Alzheimer's disease; Biomarker; Tau pathology; Phosphorylation; Neuroscience; Pathology; Disease; Psychology; Medicine; Chemistry; Central nervous system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002608792,0.0001663603,0.0002195651,0.0003269092,0.0001846488,0.000336137,0.00007984087,0.0001382024,0.0007121422],"category_scores_gemma":[0.0005184895,0.0001105687,0.00013144,0.000239077,0.0001621967,0.0001411418,0.0002119322,0.0001653282,0.000163499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001050631,"about_ca_system_score_gemma":0.00009042971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008260428,"about_ca_topic_score_gemma":0.001229193,"domain_scores_codex":[0.9998866,0.00004157995,0.00001088833,0.00002097091,0.00002430851,0.00001567175],"domain_scores_gemma":[0.9997044,0.00004301076,0.0001090705,0.00002983932,0.00005831612,0.00005535078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004882907,0.0003709855,0.4023465,0.00007909374,0.0001206836,0.0004079094,0.000321757,0.0002593594,0.5821072,0.0001935437,0.0001869794,0.008723002],"study_design_scores_gemma":[0.00001768812,0.000861212,0.9766778,0.000006277604,0.00003954795,0.0003957052,0.0001360392,0.0004261619,0.02104179,0.0001704863,0.0002229256,0.000004402161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995703,0.0000964769,0.00008817037,0.000005859557,0.000002474179,0.000003423571,0.00003662629,0.000002523767,0.0001940865],"genre_scores_gemma":[0.9997265,0.00005230761,0.00008489293,0.000006267326,0.000001618297,0.000003371111,0.00002950344,0.000001349997,0.00009415136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008260428,"threshold_uncertainty_score":0.002382398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0436556039185126,"score_gpt":0.4064402591396045,"score_spread":0.3627846552210919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}