{"id":"W4378716515","doi":"10.1016/j.isci.2023.106976","title":"Survivin prevents the polycomb repressor complex 2 from methylating histone 3 lysine 27","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Horizon 2020; HORIZON EUROPE Framework Programme; Wallenberg Centre for Molecular and Translational Medicine; Västra Götalandsregionen; Vetenskapsrådet; Röntgen-Ångström Cluster; Horizon 2020 Framework Programme; Reumatikerförbundet; Natural Sciences and Engineering Research Council of Canada; Göteborgs Universitet; Queen's University; European Commission; Stiftelsen Konung Gustaf V:s 80-årsfond","keywords":"PRC2; Histone H3; Lysine; Histone; Epigenetics; Polycomb-group proteins; Repressor; Chemistry; Survivin; Gene silencing; Histone H2A; Cell biology; EZH2; Gene expression; Biology; Gene; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009616475,0.0001626441,0.0002098867,0.0001057409,0.0001361147,0.00025661,0.0002026115,0.0001541204,0.0009382662],"category_scores_gemma":[0.0001417797,0.00009420318,0.0001728756,0.00008862458,0.0001424248,0.0001491594,0.0001799604,0.0003321736,0.0003256773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002389963,"about_ca_system_score_gemma":0.0002145919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001200681,"about_ca_topic_score_gemma":0.001671452,"domain_scores_codex":[0.999882,0.00001399335,0.00001020649,0.0000268518,0.000036228,0.00003063826],"domain_scores_gemma":[0.9999262,0.000008662568,0.00002598554,0.000009345376,0.00001131838,0.0000184802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001006478,0.00001418198,0.0009715071,0.00004108286,0.00001064349,0.00009308531,0.00001306548,0.00009472249,0.9958884,0.0001703726,0.00007438372,0.002527845],"study_design_scores_gemma":[0.00001129443,0.0001459389,0.01304358,0.000005375079,0.00001810046,0.0002705135,0.00003249905,0.00103638,0.9815344,0.00005838503,0.0038394,0.000004084432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901134,0.004273695,0.003719768,0.0000717997,0.00003475651,0.00001001029,0.0001578093,0.0000634513,0.001555447],"genre_scores_gemma":[0.997068,0.0006073438,0.0004865687,0.00003731242,0.000004680836,0.000004996424,0.0002260894,0.000008046516,0.00155709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001200681,"threshold_uncertainty_score":0.00313884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04134016278860281,"score_gpt":0.3307143359355535,"score_spread":0.2893741731469507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}