{"id":"W4378716515","doi":"10.1016/j.isci.2023.106976","title":"Survivin prevents the polycomb repressor complex 2 from methylating histone 3 lysine 27","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Horizon 2020; HORIZON EUROPE Framework Programme; Wallenberg Centre for Molecular and Translational Medicine; Västra Götalandsregionen; Vetenskapsrådet; Röntgen-Ångström Cluster; Horizon 2020 Framework Programme; Reumatikerförbundet; Natural Sciences and Engineering Research Council of Canada; Göteborgs Universitet; Queen's University; European Commission; Stiftelsen Konung Gustaf V:s 80-årsfond","keywords":"PRC2; Histone H3; Lysine; Histone; Epigenetics; Polycomb-group proteins; Repressor; Chemistry; Survivin; Gene silencing; Histone H2A; Cell biology; EZH2; Gene expression; Biology; Gene; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00062781,0.00009516037,0.00009246086,0.0000309656,0.0002035243,0.00003984179,0.0003647585,0.0000542131,0.00004686147],"category_scores_gemma":[0.0002486864,0.00007150837,0.00005462141,0.0002705492,0.0001349378,0.000004593403,0.0002364335,0.00005883914,0.00005660106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009875083,"about_ca_system_score_gemma":0.00003434685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002849205,"about_ca_topic_score_gemma":0.00008816615,"domain_scores_codex":[0.9988925,0.0001145401,0.0001783602,0.0003627422,0.0002311472,0.0002206892],"domain_scores_gemma":[0.9992642,0.00006668863,0.00009522557,0.0004798325,0.00004381265,0.00005021137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000511973,0.00001270956,0.004042303,0.000001702417,0.000008023377,6.820139e-7,0.0001117171,0.000378949,0.9869086,0.00002446344,0.0008288174,0.007676972],"study_design_scores_gemma":[0.0002432164,0.00008019691,0.1416332,0.000009799017,0.00001555275,7.233506e-7,0.00009612044,0.004124639,0.8041002,0.001408335,0.04807874,0.0002092521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928399,0.001531379,0.00299652,0.0005598087,0.0003393383,0.0001220466,0.00002684858,0.00002372214,0.001560414],"genre_scores_gemma":[0.9958819,0.0001660814,0.00100206,0.0001028779,0.0001499236,0.000009023398,0.0001133482,0.00001104454,0.002563705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1828084,"threshold_uncertainty_score":0.2916027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04134016278860281,"score_gpt":0.3307143359355535,"score_spread":0.2893741731469507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}