{"id":"W4378745836","doi":"10.1158/0008-5472.can-22-3713","title":"A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute","funders":"National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Cancer Institute; National Institute on Aging; Deutsche Krebshilfe; School of Public Health, Imperial College London; Cancer Research UK; Wageningen University and Research; National Institute for Health and Care Research; Agència de Gestió d'Ajuts Universitaris i de Recerca; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Medical Research Council; Centers for Disease Control and Prevention; National Institutes of Health; Instituto de Salud Carlos III; World Health Organization; Xarxa de Bancs de Tumors de Catalunya; Junta de Castilla y León; Grantová Agentura České Republiky; Herzfelder'sche Familienstiftung; Institut Gustave-Roussy; National Human Genome Research Institute; Cancer Council Victoria; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Mutuelle Générale de l'Education Nationale; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Ministerstvo Zdravotnictví Ceské Republiky; Canadian Institutes of Health Research; Cancerfonden; NIHR Imperial Biomedical Research Centre; Johns Hopkins University; Centre International de Recherche sur le Cancer; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; Food Standards Agency; Harvard T.H. Chan School of Public Health; Génome Québec; Univerzita Karlova v Praze; McGill University; University of Pittsburgh; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Fred Hutchinson Cancer Research Center; Imperial College London; U.S. Department of Health and Human Services; Office of Research Infrastructure Programs, National Institutes of Health; American Institute for Cancer Research; Damon Runyon Cancer Research Foundation; Brigham and Women's Hospital; American Cancer Society","keywords":"Colorectal cancer; Locus (genetics); Body mass index; Gene; Biology; Cancer; Medicine; Oncology; Genetics; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001847435,0.0005535244,0.0004578289,0.0008189885,0.0003443719,0.0004216567,0.0003959392,0.000686453,0.001563483],"category_scores_gemma":[0.006093107,0.0002392902,0.00119725,0.0009927067,0.0004595157,0.0001868681,0.000509979,0.0007337602,0.0001496251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002386552,"about_ca_system_score_gemma":0.0002999779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003082889,"about_ca_topic_score_gemma":0.00377976,"domain_scores_codex":[0.9983194,0.0008378226,0.00007508012,0.0004721027,0.0001514569,0.0001440011],"domain_scores_gemma":[0.9966868,0.001751745,0.0009272221,0.0003338783,0.0001001615,0.0002002925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003221458,0.0001254949,0.9600966,0.00009913481,0.001253612,0.0006561044,0.0002431015,0.000442844,0.02075321,0.000222235,0.000246372,0.01263981],"study_design_scores_gemma":[0.0000621552,0.0001485051,0.996278,0.0000127192,0.0003845125,0.0004680135,0.00003494877,0.001130802,0.0009941958,0.0001570272,0.0003194438,0.000009640939],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970145,0.0008930746,0.001210465,0.0001558352,0.00002484621,0.00001302856,0.0002530985,0.00002623574,0.0004088468],"genre_scores_gemma":[0.9983835,0.0001300559,0.001015417,0.00005998758,0.00001919493,0.00001349536,0.0001956881,0.000009760368,0.0001728859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003082889,"threshold_uncertainty_score":0.009770274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03687123721568086,"score_gpt":0.3670161089392511,"score_spread":0.3301448717235702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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