{"id":"W4378781281","doi":"10.1098/rsob.230031","title":"Structural insights into a regulatory mechanism of FIR RRM1–FUSE interaction","year":2023,"lang":"en","type":"article","venue":"Open Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genentech; Innovative Medicines Initiative; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Structural Genomics Consortium; Merck KGaA; Ontario Genomics; Genome Canada; McGill University; Bayer; Pfizer; Deutsche Forschungsgemeinschaft; Bristol-Myers Squibb","keywords":"Biology; DNA; Genetics; Transcription factor; Binding site; Cell biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000198313,0.0001346173,0.0002033743,0.00007343537,0.00008251394,0.00001779586,0.0004553314,0.0002352619,0.0001003872],"category_scores_gemma":[0.00007503128,0.0001133242,0.00006920739,0.0001207581,0.00006307103,0.000008687683,0.0004562329,0.00005943072,0.00005552147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001069895,"about_ca_system_score_gemma":0.00004711435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001600132,"about_ca_topic_score_gemma":0.0001400559,"domain_scores_codex":[0.9990418,0.0001515571,0.000227783,0.0003444117,0.00005437762,0.0001801019],"domain_scores_gemma":[0.9993359,0.00002161001,0.0001351898,0.0003995724,0.00005704334,0.0000506325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001067878,0.000009043097,0.00008664042,0.0000100697,0.00004426665,0.000001915935,0.00009805685,0.000004270552,0.9807272,0.01046496,0.000709472,0.007737298],"study_design_scores_gemma":[0.000315727,0.0003813058,0.0006452472,0.00001451955,0.000008734759,0.00000778381,0.0001384277,0.00006720982,0.9513809,0.02374722,0.02313676,0.0001561754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967566,0.0001435914,0.0003900498,0.0001725818,0.0004941694,0.0003052093,0.000008678689,0.00001824254,0.001710895],"genre_scores_gemma":[0.9976861,0.0001287867,0.0008155036,0.0001721131,0.0001149262,0.00005176065,0.0002085744,0.00001848875,0.0008036804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02934633,"threshold_uncertainty_score":0.4621229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02318997329741029,"score_gpt":0.2977571025061507,"score_spread":0.2745671292087404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}