{"id":"W4378782045","doi":"10.1161/hypertensionaha.122.20449","title":"Notch3/Hes5 Induces Vascular Dysfunction in Hypoxia-Induced Pulmonary Hypertension Through ER Stress and Redox-Sensitive Pathways","year":2023,"lang":"en","type":"article","venue":"Hypertension","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Medical Research Council; Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale; University of Glasgow; British Heart Foundation; McGill University","keywords":"Fasudil; Pulmonary hypertension; Endocrinology; Pulmonary artery; Internal medicine; Hypoxic pulmonary vasoconstriction; Hypoxia (environmental); Medicine; Oxidative stress; Vascular smooth muscle; Unfolded protein response; Nitric oxide; Reactive oxygen species; Rho-associated protein kinase; Pharmacology; Chemistry; Signal transduction; Biology; Endoplasmic reticulum; Cell biology; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004327674,0.0005329503,0.0009438192,0.0006510077,0.0003453214,0.00004640803,0.0001141364,0.0004526077,0.0000338746],"category_scores_gemma":[0.0003599258,0.0004159987,0.0002134357,0.001269991,0.0001527978,0.0004767062,0.0002897689,0.0006550095,0.0003773466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001379999,"about_ca_system_score_gemma":0.0001528448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005322562,"about_ca_topic_score_gemma":0.00003184539,"domain_scores_codex":[0.9960482,0.0002577428,0.000549602,0.001171701,0.001031339,0.0009414869],"domain_scores_gemma":[0.9979967,0.0003045643,0.0001124015,0.0007426363,0.00040827,0.0004354228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001168117,0.001509277,0.009705519,0.0002002532,0.0002380695,0.04088074,0.0002335172,0.00001552033,0.9202076,0.00004586302,0.002672051,0.02312342],"study_design_scores_gemma":[0.00786282,0.001520748,0.9168243,0.001713001,0.0003870436,0.00487011,0.003102932,0.0127732,0.04734339,0.000810746,0.001883927,0.000907794],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935606,0.0008282054,0.0000072138,0.001972278,0.0004097297,0.001062964,0.00003436868,0.0003519185,0.001772776],"genre_scores_gemma":[0.9943705,0.002841386,0.0003335032,0.001344377,0.0002028395,0.00007551,0.0004660261,0.0001000752,0.0002657436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9071188,"threshold_uncertainty_score":0.9998292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06191541473307526,"score_gpt":0.272447480416827,"score_spread":0.2105320656837518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}