{"id":"W4378782045","doi":"10.1161/hypertensionaha.122.20449","title":"Notch3/Hes5 Induces Vascular Dysfunction in Hypoxia-Induced Pulmonary Hypertension Through ER Stress and Redox-Sensitive Pathways","year":2023,"lang":"en","type":"article","venue":"Hypertension","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Medical Research Council; Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale; University of Glasgow; British Heart Foundation; McGill University","keywords":"Fasudil; Pulmonary hypertension; Endocrinology; Pulmonary artery; Internal medicine; Hypoxic pulmonary vasoconstriction; Hypoxia (environmental); Medicine; Oxidative stress; Vascular smooth muscle; Unfolded protein response; Nitric oxide; Reactive oxygen species; Rho-associated protein kinase; Pharmacology; Chemistry; Signal transduction; Biology; Endoplasmic reticulum; Cell biology; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001571375,0.0002201825,0.0001463285,0.0001637364,0.0001065185,0.0001507592,0.000148965,0.0002414477,0.001137188],"category_scores_gemma":[0.00006827661,0.0001164055,0.0002232384,0.00008620272,0.0002364246,0.0001294642,0.0001861395,0.000434851,0.0001544307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002182962,"about_ca_system_score_gemma":0.0001167743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003014398,"about_ca_topic_score_gemma":0.0004999609,"domain_scores_codex":[0.9998969,0.00002142277,0.00001281924,0.00001842784,0.00002403614,0.00002625397],"domain_scores_gemma":[0.9998863,0.00001102525,0.00004133978,0.00000999878,0.000008353862,0.0000429871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002374683,0.00002547319,0.0004337129,0.00002107164,0.000005046657,0.0001280305,0.000008614375,0.00002432721,0.9986588,0.00004576096,0.00002477943,0.0003869123],"study_design_scores_gemma":[0.00005990463,0.0008470701,0.02430826,0.00001177296,0.00003829551,0.001018904,0.00005662744,0.0009707845,0.971565,0.00009492956,0.001024018,0.00000437309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980807,0.0003507505,0.000891799,0.00005414678,0.00001091095,0.00001529035,0.0001363314,0.00003304536,0.0004270623],"genre_scores_gemma":[0.9980014,0.0002253935,0.0006564105,0.00005314142,0.000006275048,0.00002402148,0.000222572,0.000006659514,0.0008040756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001137188,"threshold_uncertainty_score":0.003804326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06191541473307526,"score_gpt":0.272447480416827,"score_spread":0.2105320656837518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}