{"id":"W4378782678","doi":"10.3389/fphar.2023.1119607","title":"A novel cell-based screen identifies chemical entities that reverse the immune-escape phenotype of metastatic tumours","year":2023,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Invertebrate Immune Response Mechanisms","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Vancouver Coastal Health Research Institute; University of British Columbia; Simon Fraser University; Vancouver Coastal Health","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Immune system; Cancer research; Biology; Downregulation and upregulation; Cancer; Metastasis; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001040751,0.000284975,0.0006129633,0.0005302546,0.0001538065,0.00001379341,0.0007792361,0.0002162106,0.0008687343],"category_scores_gemma":[0.00008273971,0.0002382886,0.0002070621,0.0006255617,0.0007897381,0.0001106223,0.0002399983,0.0005486949,0.0003328375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008954036,"about_ca_system_score_gemma":0.0002016363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002310621,"about_ca_topic_score_gemma":0.000009482739,"domain_scores_codex":[0.9976261,0.0006956486,0.0005373071,0.0003676564,0.00009682672,0.0006764486],"domain_scores_gemma":[0.9988601,0.0004030211,0.0002814776,0.000355517,0.00007630623,0.00002358552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000798928,0.0001805188,0.0003045892,0.00005588199,0.0002597633,0.00002590951,0.000697288,0.000138948,0.9000643,0.0001959454,0.09708835,0.0001895567],"study_design_scores_gemma":[0.00354251,0.0000914651,0.0005938673,0.00002891613,0.0002534128,0.00001730257,0.002787088,0.0006724022,0.9856535,0.0004273226,0.00569733,0.0002349156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9637264,0.01039019,0.007180066,0.002156359,0.01417682,0.001308144,0.0002193865,0.0002505788,0.0005920277],"genre_scores_gemma":[0.9945272,0.0002081484,0.001012425,0.0006406436,0.00002684994,0.000132115,0.0001883828,0.00004654172,0.003217686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09139102,"threshold_uncertainty_score":0.9717126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01975165870758614,"score_gpt":0.2580401069987593,"score_spread":0.2382884482911732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}