{"id":"W4378782735","doi":"10.1073/pnas.2221742120","title":"Fibrillin-1 regulates endothelial sprouting during angiogenesis","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Fondation de France; Ligue Contre le Cancer; Marfan Foundation; Institut National de la Santé et de la Recherche Médicale; Fondation Lefoulon Delalande; Glaucoma Foundation","keywords":"Fibrillin; Angiogenesis; Extracellular matrix; Cell biology; Microfibril; Biology; Endothelial stem cell; Sprouting angiogenesis; Matrix metalloproteinase; Marfan syndrome; Chemistry; Neovascularization; Cancer research; Internal medicine; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008533649,0.0003206032,0.0001330027,0.0002018954,0.0003081259,0.0002680866,0.0001616026,0.0002643359,0.000620244],"category_scores_gemma":[0.00007919988,0.0001205544,0.0001665325,0.00006954684,0.0001567531,0.0001537301,0.0001750674,0.0005087783,0.0002668282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004716909,"about_ca_system_score_gemma":0.0001447948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000902037,"about_ca_topic_score_gemma":0.0009332356,"domain_scores_codex":[0.9999006,0.00001508893,0.000005819641,0.00002527937,0.00002415275,0.00002897526],"domain_scores_gemma":[0.9999158,0.000007044882,0.00002496761,0.000005243177,0.00001519219,0.00003179336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006592797,0.00001133845,0.0003071287,0.00001636232,0.000002502901,0.00009425697,0.00001561484,0.00006501538,0.9977849,0.0001276103,0.00007269624,0.001436686],"study_design_scores_gemma":[0.00002095942,0.0001554955,0.02916879,0.00001538425,0.00002051776,0.0004988505,0.00005280254,0.00221081,0.9617734,0.0002556136,0.005817768,0.000009544748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861921,0.005603002,0.004326846,0.0001894927,0.00005673668,0.00002416129,0.0002990442,0.0002023231,0.003106304],"genre_scores_gemma":[0.994419,0.001259488,0.001429412,0.00005064257,0.00001381066,0.00001614738,0.000213015,0.00001627564,0.002582174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000902037,"threshold_uncertainty_score":0.003422439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04003605703540773,"score_gpt":0.3270757601418688,"score_spread":0.287039703106461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}