{"id":"W4378832621","doi":"10.1101/2023.05.30.542914","title":"Wnt binding to Coatomer proteins directs secretion on exosomes independently of palmitoylation","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Ontario Institute for Regenerative Medicine; Stem Cell Network","keywords":"Secretion; Palmitoylation; Cell biology; Wnt signaling pathway; Biology; Microvesicles; Plasma protein binding; Biochemistry; Signal transduction; Cysteine; Enzyme; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002066663,0.0003062416,0.0001818355,0.0001628711,0.0002819553,0.0004239438,0.0001406279,0.0002977086,0.002301555],"category_scores_gemma":[0.0002721715,0.0001897375,0.0003515936,0.00009208262,0.0002863371,0.0002114908,0.0004260334,0.0004924025,0.001101604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004130363,"about_ca_system_score_gemma":0.0002755551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00109139,"about_ca_topic_score_gemma":0.001195968,"domain_scores_codex":[0.9997935,0.0000311244,0.00001455123,0.00003534763,0.00007819221,0.00004729468],"domain_scores_gemma":[0.9998553,0.00002995169,0.00002411329,0.0000234024,0.00002672628,0.00004060699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004696807,0.000008351045,0.0003736711,0.00003212792,0.000006653781,0.00008262609,0.00001378847,0.00004309112,0.9980403,0.0004628576,0.000147388,0.00074225],"study_design_scores_gemma":[0.0000123007,0.00002698219,0.006003703,0.000009340031,0.000008575866,0.0002596588,0.00002275385,0.002136225,0.9863842,0.0001726335,0.004959337,0.000004110655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816558,0.001407694,0.0103611,0.0004752532,0.00009389633,0.00003782573,0.0003001314,0.000176792,0.005491574],"genre_scores_gemma":[0.9835878,0.0006948427,0.005495495,0.0001379122,0.00002670059,0.00002424104,0.0006333315,0.00009471653,0.009304986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002301555,"threshold_uncertainty_score":0.00769943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01695305600718276,"score_gpt":0.2432495864554294,"score_spread":0.2262965304482467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}