{"id":"W4378833684","doi":"10.1101/2023.05.29.542735","title":"Antibodies against SARS-CoV-2 control complement-induced inflammatory responses to SARS-CoV-2","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; ZonMw; Universität Innsbruck; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Österreichischen Akademie der Wissenschaften; Amsterdam University Medical Centers","keywords":"Innate immune system; Opsonin; Immunology; Acquired immune system; Immunity; Immune system; Complement system; Antibody; Complement receptor; Classical complement pathway; Biology; Antibody opsonization; Cytokine storm; Alternative complement pathway; Inflammation; Humoral immunity; Complement receptor 1; Virology; Medicine; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002013846,0.0003839766,0.0002357307,0.0001901791,0.0001567976,0.0002883971,0.0001502441,0.0002551008,0.002339137],"category_scores_gemma":[0.000155582,0.0001221091,0.0002255619,0.00009531979,0.0002548147,0.0001166249,0.0002019074,0.0005756738,0.0006913152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003852988,"about_ca_system_score_gemma":0.0002737838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000654356,"about_ca_topic_score_gemma":0.0008501488,"domain_scores_codex":[0.9998105,0.00004093774,0.00002064034,0.00002779517,0.0000351113,0.00006495797],"domain_scores_gemma":[0.9999019,0.000009282564,0.00003051954,0.00001319784,0.00001457717,0.00003050976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006039271,0.0001206611,0.0003743057,0.00004245838,0.000005888501,0.00005077989,0.00001268609,0.00006905512,0.9968351,0.0001101295,0.0001789386,0.001596207],"study_design_scores_gemma":[0.0002811218,0.001384869,0.02098103,0.00002458786,0.00003011833,0.0005100492,0.00005917659,0.002981605,0.9677913,0.0001608316,0.005785943,0.000009358703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946872,0.001502605,0.001102895,0.0002002853,0.00004836611,0.00008343449,0.0003907329,0.00007972726,0.001904861],"genre_scores_gemma":[0.9948284,0.0005499053,0.001399247,0.0001532664,0.0000279231,0.0000818431,0.0005635784,0.00001593881,0.002379879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002339137,"threshold_uncertainty_score":0.007825136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07521913655188851,"score_gpt":0.341795081722224,"score_spread":0.2665759451703355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}