{"id":"W4378834477","doi":"10.1101/2023.05.29.23290698","title":"Introduction of a Penicillin Allergy De-Labelling Program with Direct Oral Challenge is Associated with Increased Downstream Utilization of Beta-Lactam Antimicrobials: A Multicenter Parallel Cohort Study with Crossover Evaluation","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Ottawa Hospital; University of Ottawa","funders":"","keywords":"Medicine; Penicillin; Antibiotics; Amoxicillin; Internal medicine; Allergy; Retrospective cohort study; Odds ratio; Pediatrics; Immunology; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005568932,0.001218393,0.0009840248,0.0005932731,0.0007915583,0.001326398,0.0006982404,0.001068284,0.001474131],"category_scores_gemma":[0.005871703,0.0007511542,0.001662951,0.0006366847,0.001004897,0.000950869,0.000905077,0.001265846,0.0003126331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009300892,"about_ca_system_score_gemma":0.001174683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002541579,"about_ca_topic_score_gemma":0.002189495,"domain_scores_codex":[0.995975,0.002081662,0.0002796692,0.0007803882,0.0003748671,0.0005084776],"domain_scores_gemma":[0.994374,0.001091144,0.001824094,0.001154532,0.0005308951,0.001025317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1000853,0.02108665,0.8657873,0.000125944,0.001563179,0.0002527504,0.0008359113,0.0001730273,0.00298343,0.00006984089,0.0004793551,0.006557339],"study_design_scores_gemma":[0.007193067,0.1007403,0.8877189,0.00003205516,0.000878775,0.0001768574,0.0007197125,0.0007766846,0.001241934,0.00005746348,0.0004151322,0.00004907182],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995462,0.00006149303,0.00009497244,0.0000118864,0.00001447912,0.0001276564,0.00006253251,0.000003969708,0.00007671726],"genre_scores_gemma":[0.9991649,0.0000468779,0.0002304855,0.00003868321,0.00003535433,0.0001580818,0.0001804991,0.000002964939,0.0001421669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005568932,"threshold_uncertainty_score":0.02945173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0702570897791572,"score_gpt":0.3415258741040708,"score_spread":0.2712687843249135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}