{"id":"W4378835148","doi":"10.20944/preprints202305.1990.v1","title":"The Central Role of the Kynurenine Pathway of Tryptophan Metabolism in the Pathophysiology of Frailty, Sarcopenia and Osteoporosis","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Sarcopenia; Kynurenine; Osteoporosis; Medicine; Anabolism; Internal medicine; Kynurenine pathway; Niacin; Endocrinology; Catabolism; Tryptophan; Metabolism; Biology; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031921,0.0002532471,0.0004233852,0.0003639473,0.00024945,0.0007955957,0.0001655224,0.0005334119,0.002778895],"category_scores_gemma":[0.0005594104,0.000108131,0.0003093386,0.0002102464,0.0006710252,0.000461836,0.0006467985,0.0007176063,0.0007558315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003283068,"about_ca_system_score_gemma":0.0008361656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001205711,"about_ca_topic_score_gemma":0.000956658,"domain_scores_codex":[0.9998631,0.0000405625,0.00000986404,0.0000264907,0.00003388118,0.00002597934],"domain_scores_gemma":[0.999842,0.00002653869,0.00003349147,0.00001770426,0.00003253918,0.00004767857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.004734948,0.0003467029,0.03809997,0.008708855,0.001122229,0.008047722,0.002865697,0.002173947,0.3659388,0.05447959,0.04684128,0.4666402],"study_design_scores_gemma":[0.0005143285,0.0012145,0.4428535,0.003571851,0.0006033531,0.02012022,0.002697365,0.004223767,0.07247961,0.1751714,0.2763525,0.0001975921],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5040329,0.3939513,0.02888687,0.02470522,0.002246797,0.0001651425,0.003399405,0.0008105749,0.04180185],"genre_scores_gemma":[0.8881364,0.08980832,0.006753077,0.001084765,0.0008672304,0.0001134709,0.001225609,0.0001358329,0.01187533],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002778895,"threshold_uncertainty_score":0.009296298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0798588093477227,"score_gpt":0.3077438574276822,"score_spread":0.2278850480799595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}