{"id":"W4378878919","doi":"10.3390/ijms24119511","title":"The Placenta—A New Source of Bile Acids during Healthy Pregnancy? First Results of a Gene Expression Study in Humans and Mice","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Natural Sciences and Engineering Research Council of Canada; National Science Foundation; National Institutes of Health; Stiftung Lindenhof Bern; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Placenta; Cholesterol 7 alpha-hydroxylase; Hydroxylation; Bile acid; Oxysterol; Enzyme; Biology; Pregnancy; Cholesterol; Internal medicine; Gene; Endocrinology; Fetus; Chemistry; Biochemistry; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005081497,0.0004413333,0.000370862,0.0007802519,0.0002173518,0.0005095777,0.0001909327,0.0004673185,0.001095322],"category_scores_gemma":[0.0002376357,0.0003687308,0.0004290442,0.0002842834,0.000516858,0.0003364995,0.0002437989,0.0005227943,0.0004070086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002852619,"about_ca_system_score_gemma":0.0001641313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005311038,"about_ca_topic_score_gemma":0.0003840595,"domain_scores_codex":[0.9997711,0.00004402099,0.00001942839,0.00009264339,0.00004338466,0.00002948454],"domain_scores_gemma":[0.9998192,0.00004054806,0.00005346223,0.00003316934,0.00002329828,0.00003030062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001015699,0.00003310914,0.002959203,0.000162448,0.00004354281,0.0003116012,0.0001184466,0.00005573902,0.9825149,0.000590949,0.0001601628,0.01203413],"study_design_scores_gemma":[0.0001104717,0.001900556,0.09305941,0.0001062901,0.0004142071,0.006957407,0.0003118831,0.0007348756,0.8591686,0.001277642,0.03591458,0.00004402094],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9181425,0.04757486,0.02467681,0.001318683,0.0001164951,0.00006425922,0.002339096,0.0003070865,0.005460214],"genre_scores_gemma":[0.9575491,0.02391002,0.01005618,0.0005879661,0.00008006422,0.00008934893,0.001809887,0.0001391337,0.005778279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001095322,"threshold_uncertainty_score":0.003664255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01944926006369539,"score_gpt":0.3028672804913514,"score_spread":0.283418020427656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}