{"id":"W4378901208","doi":"10.1172/jci170643","title":"Two to tango: endothelial cell TMEM16 scramblases drive coagulation and thrombosis","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Phospholipid scramblase; Phosphatidylserine; Thrombus; Coagulation; Platelet; Endothelial stem cell; Thrombosis; Fibrin; Immunology; Cell biology; Platelet activation; Biology; Medicine; Internal medicine; Biochemistry; Phospholipid; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003771903,0.0004091318,0.0003386432,0.0003341805,0.0004639399,0.001152138,0.0003839409,0.001169878,0.004126887],"category_scores_gemma":[0.0004760051,0.0002306261,0.0002722086,0.0001336051,0.0005605198,0.0007773509,0.0003894499,0.002088024,0.001046067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004433537,"about_ca_system_score_gemma":0.0003135447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002365015,"about_ca_topic_score_gemma":0.0005408476,"domain_scores_codex":[0.9997768,0.00003095758,0.00003067173,0.00005177738,0.00006831773,0.00004154625],"domain_scores_gemma":[0.9996551,0.0000568245,0.00008485709,0.00003783025,0.00005322567,0.000112043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001155285,0.0002208629,0.001288179,0.0004193917,0.00008535432,0.001073277,0.0001913054,0.0001719323,0.9014115,0.007868247,0.03336469,0.05275002],"study_design_scores_gemma":[0.0003235463,0.0007369335,0.006835654,0.0001031081,0.0001349303,0.003234817,0.0001723847,0.002218857,0.6739746,0.002915405,0.3093084,0.00004136569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7265612,0.08538863,0.03359841,0.07272464,0.0267662,0.0003589453,0.002121597,0.003422101,0.04905822],"genre_scores_gemma":[0.8760009,0.02356622,0.01358708,0.01384178,0.003652742,0.0001842986,0.001461099,0.000371068,0.06733476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004126887,"threshold_uncertainty_score":0.01380581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07921616306726385,"score_gpt":0.3855916389039084,"score_spread":0.3063754758366445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}