{"id":"W4378902617","doi":"10.1080/19382014.2023.2219477","title":"GABA treatment does not induce neogenesis of new endocrine cells from pancreatic ductal cells","year":2023,"lang":"en","type":"article","venue":"Islets","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Neogenesis; Endocrinology; Internal medicine; Ductal cells; Enteroendocrine cell; Pancreas; Biology; PAX4; Glucagon; Endocrine system; Islet; Alpha cell; Beta cell; Insulin; Medicine; Hormone; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273487,0.000357649,0.0004704263,0.0002780728,0.0001084233,0.0003119712,0.0002396078,0.0003462837,0.001976694],"category_scores_gemma":[0.0002286826,0.0001742502,0.0002927769,0.000161697,0.0003009915,0.0002326036,0.0002875751,0.001070645,0.0005219208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002249464,"about_ca_system_score_gemma":0.0002680414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005599999,"about_ca_topic_score_gemma":0.001773227,"domain_scores_codex":[0.9997744,0.00003432256,0.00002582662,0.00004973201,0.00005955344,0.00005610728],"domain_scores_gemma":[0.9995381,0.0001155058,0.0001120887,0.00005700156,0.00004066207,0.0001367068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002904983,0.00005931742,0.0003151492,0.00009623661,0.00001065592,0.0001339655,0.00004099244,0.00003421458,0.9964771,0.00006506561,0.0000620362,0.002414896],"study_design_scores_gemma":[0.00005529683,0.001749335,0.01063803,0.00002967457,0.00003112266,0.000539436,0.00009660682,0.0002641319,0.979993,0.00005476128,0.006539931,0.000008773961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926621,0.002329128,0.001332955,0.0001865141,0.00009539283,0.00003622607,0.0004778686,0.00011759,0.002762154],"genre_scores_gemma":[0.9849793,0.001946851,0.002964844,0.0002636466,0.00002987193,0.0001092354,0.0009683624,0.0001077289,0.00863011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001976694,"threshold_uncertainty_score":0.006612718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.028874706691898,"score_gpt":0.265900531895979,"score_spread":0.2370258252040809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}