{"id":"W4378904483","doi":"10.3390/v15061281","title":"Generation of a SARS-CoV-2 Reverse Genetics System and Novel Human Lung Cell Lines That Exhibit High Virus-Induced Cytopathology","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; National Cancer Institute; Innovation Saskatchewan; Glaucoma Research Foundation","keywords":"Virology; Virus; Biology; Cell culture; Cytopathology; HEK 293 cells; Reverse genetics; CRISPR; Viral replication; A549 cell; Genetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003562991,0.0002047872,0.0004233284,0.000376751,0.0001242461,0.00003201757,0.0001321942,0.0002006156,0.000003087667],"category_scores_gemma":[0.00007510994,0.000182718,0.00007365747,0.0003992167,0.0001051712,0.00008627769,0.0001450828,0.0001801776,0.00006126129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007261471,"about_ca_system_score_gemma":0.0001195788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008381833,"about_ca_topic_score_gemma":0.0002019951,"domain_scores_codex":[0.9984374,0.00008126446,0.0003661546,0.0004101226,0.0003753974,0.0003296566],"domain_scores_gemma":[0.9991495,0.00008789296,0.0001346051,0.0004414106,0.0001531439,0.00003347064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007935293,0.00009508567,0.02184667,0.0005221293,0.00003043516,0.0001146151,0.0002444361,0.00000163925,0.9756184,0.0002350952,0.001026338,0.0001858095],"study_design_scores_gemma":[0.001463391,0.0002890256,0.005717539,0.0001177563,0.00009259272,0.00003543942,0.0001873667,0.001583262,0.9859411,0.00001012916,0.0044006,0.0001617639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982082,0.0004365156,0.0001206838,0.00006024203,0.0002247123,0.0004662716,0.00005079565,0.0001534922,0.0002791047],"genre_scores_gemma":[0.9921547,0.00002623132,0.0002162879,0.0070747,0.0003956533,0.00004436487,0.00001239246,0.00004776038,0.00002789544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01612913,"threshold_uncertainty_score":0.7451022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2101888840699943,"score_gpt":0.391050238881669,"score_spread":0.1808613548116747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}