{"id":"W4378904483","doi":"10.3390/v15061281","title":"Generation of a SARS-CoV-2 Reverse Genetics System and Novel Human Lung Cell Lines That Exhibit High Virus-Induced Cytopathology","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; National Cancer Institute; Innovation Saskatchewan; Glaucoma Research Foundation","keywords":"Virology; Virus; Biology; Cell culture; Cytopathology; HEK 293 cells; Reverse genetics; CRISPR; Viral replication; A549 cell; Genetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006580618,0.0004595356,0.0004558101,0.0003606843,0.000255461,0.0004934897,0.0005128759,0.0005334917,0.001620551],"category_scores_gemma":[0.000322769,0.0002423225,0.0004332074,0.0003136798,0.000212982,0.0002757217,0.0003589376,0.0009619,0.00134235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003719819,"about_ca_system_score_gemma":0.0003732786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001374051,"about_ca_topic_score_gemma":0.002083364,"domain_scores_codex":[0.9994653,0.0001137378,0.00007479724,0.00008719717,0.0001967625,0.00006221203],"domain_scores_gemma":[0.9997473,0.00005093253,0.00003696339,0.00006844837,0.00006181602,0.00003448417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000630198,0.00007696843,0.000280157,0.0000337637,0.000007096451,0.00008792192,0.00003847638,0.0001450593,0.9975229,0.0002658671,0.0002295387,0.001249218],"study_design_scores_gemma":[0.00004160114,0.0004118517,0.002193674,0.000009392639,0.00002115744,0.000554884,0.00004746162,0.002154586,0.9872214,0.00006297437,0.007267181,0.00001385348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9099696,0.001642097,0.07192192,0.0006637904,0.0002120883,0.001224674,0.007878668,0.0007901116,0.005697159],"genre_scores_gemma":[0.8998706,0.001530088,0.06994036,0.0002532276,0.00004240662,0.001013479,0.01710733,0.000176133,0.01006638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001620551,"threshold_uncertainty_score":0.00542134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2101888840699943,"score_gpt":0.391050238881669,"score_spread":0.1808613548116747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}