{"id":"W4378905604","doi":"10.3390/jpm13060918","title":"Pharmacogenetics of Lethal Opioid Overdose: Review of Current Evidence and Preliminary Results from a Pilot Study","year":2023,"lang":"en","type":"article","venue":"Journal of Personalized Medicine","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Office of the Chief Medical Examiner; Public Health Ontario; University of Toronto; Waypoint Centre for Mental Health Care; Centre for Addiction and Mental Health","funders":"","keywords":"Medicine; Pharmacogenetics; Opioid overdose; Opioid; Methadone; Population; Pharmacology; Accidental; Anesthesia; Emergency medicine; Internal medicine; Environmental health; Genotype; (+)-Naloxone; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002790239,0.0001847988,0.001010977,0.0003139125,0.00002642201,0.000002655338,0.000187984,0.00002435063,0.0001884786],"category_scores_gemma":[0.002893721,0.000127145,0.000111692,0.0005235452,0.0002155886,0.00008050587,0.00009760972,0.0002992404,0.000002586157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003713729,"about_ca_system_score_gemma":0.0001573215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004634424,"about_ca_topic_score_gemma":9.269611e-7,"domain_scores_codex":[0.9969454,0.0002133583,0.001289677,0.0002051702,0.001170326,0.0001761021],"domain_scores_gemma":[0.9972361,0.0008261804,0.001024913,0.000251391,0.0004569613,0.0002044755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.07309923,0.007624834,0.2456697,0.07116116,0.003824087,0.003158569,0.03043872,0.00001350134,0.09742021,0.00008005196,0.3976821,0.06982783],"study_design_scores_gemma":[0.04562733,0.05064389,0.6532066,0.2110767,0.008060796,0.00009553767,0.004439696,0.0004801813,0.001048897,0.000152447,0.02482031,0.0003476045],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7373648,0.2580354,0.00004642055,0.003389839,0.000393897,0.0006514209,0.00002137864,0.00001069804,0.00008618242],"genre_scores_gemma":[0.679521,0.3188745,0.0002682594,0.0004036654,0.0006075631,0.000004678353,0.00001722775,0.00001693383,0.0002861578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4075369,"threshold_uncertainty_score":0.5184821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1523544392738652,"score_gpt":0.4195917204540955,"score_spread":0.2672372811802303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}