{"id":"W4378952773","doi":"10.1111/bjh.18900","title":"Genome‐wide <scp>CRISPR</scp> screening uncovers potential targets and mechanisms of vincristine resistance in <scp>DLBCL</scp>","year":2023,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Vincristine; CRISPR; Drug resistance; Cancer research; Biology; Medicine; Cell cycle checkpoint; Computational biology; Apoptosis; Bioinformatics; Cell cycle; Internal medicine; Genetics; Chemotherapy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002852408,0.0009005651,0.001128527,0.0005964632,0.001424669,0.002429247,0.002369305,0.01378228,0.005403219],"category_scores_gemma":[0.007546044,0.0004942295,0.001010305,0.0003837062,0.00165832,0.00151487,0.001016186,0.01478203,0.00274764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00161666,"about_ca_system_score_gemma":0.002000259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002353584,"about_ca_topic_score_gemma":0.006959194,"domain_scores_codex":[0.9986929,0.0002076652,0.0001318657,0.0001966555,0.0005750767,0.0001958466],"domain_scores_gemma":[0.9939781,0.003224089,0.0003286946,0.0001836098,0.001573359,0.0007121089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001225004,0.00002494766,0.0002513457,0.0001225376,0.00002064678,0.000384776,0.00004296225,0.00008273905,0.001208655,0.0009604519,0.981294,0.01548435],"study_design_scores_gemma":[0.00015652,0.0001451324,0.001701201,0.0001914556,0.00008090213,0.0007877421,0.0001694706,0.0005514401,0.002114136,0.005045322,0.9890036,0.00005314412],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.001865455,0.01232743,0.00137593,0.7499598,0.2300224,0.00005925849,0.0006525996,0.0003891776,0.003347963],"genre_scores_gemma":[0.01582139,0.02212578,0.001905819,0.6107071,0.323308,0.0001157112,0.0005476857,0.0001915769,0.02527701],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01378228,"threshold_uncertainty_score":0.01807559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01549574371900197,"score_gpt":0.2745881203926939,"score_spread":0.2590923766736919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}