{"id":"W4378978755","doi":"10.1021/acs.bioconjchem.3c00135","title":"Changes in Potency and Subtype Selectivity of Bivalent Na<sub>V</sub> Toxins are Knot-Specific","year":2023,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; National Health and Medical Research Council; National Institutes of Health; Australian Research Council; University of Queensland","keywords":"Chemistry; Bivalent (engine); Potency; Native chemical ligation; Spider toxin; Selectivity; Peptide; Conotoxin; Sodium channel; Gating; Stereochemistry; Biophysics; Biochemistry; Sodium; In vitro; Receptor; Chemical synthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002748006,0.0002522202,0.000311503,0.00005746383,0.0000523955,0.00001409491,0.0002001863,0.0002746825,0.00001730321],"category_scores_gemma":[0.0001176771,0.0002624475,0.00007887353,0.0003724114,0.0001418051,0.000004294085,0.0002782241,0.0001719004,0.00001466369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000346001,"about_ca_system_score_gemma":0.0000694535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000145338,"about_ca_topic_score_gemma":0.00006114699,"domain_scores_codex":[0.998535,0.00004498703,0.000277184,0.0005892368,0.0001652963,0.0003883069],"domain_scores_gemma":[0.9991941,0.00002332575,0.0001777616,0.0004083227,0.00008992155,0.0001065798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000581186,0.0001133531,0.01915115,0.0001580067,0.00003383381,0.000002821036,0.00004841296,0.000003675631,0.9767457,0.000003367701,0.001067931,0.002613599],"study_design_scores_gemma":[0.0006772704,0.00008358144,0.01287199,0.00005431087,0.00001016075,0.00001130965,0.0001858218,0.00001472904,0.9823563,0.00001598844,0.003452836,0.0002657704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976528,0.001188751,0.000009201861,0.0002441483,0.000101177,0.000243848,0.00006907724,0.00004139401,0.0004496369],"genre_scores_gemma":[0.9953665,0.00388941,0.00003290602,0.00003441817,0.0002193674,0.00004429327,0.000112108,0.0000386897,0.0002622806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006279157,"threshold_uncertainty_score":0.9999828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350359486011981,"score_gpt":0.2382136888138207,"score_spread":0.2247100939537009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}