{"id":"W4378978755","doi":"10.1021/acs.bioconjchem.3c00135","title":"Changes in Potency and Subtype Selectivity of Bivalent Na<sub>V</sub> Toxins are Knot-Specific","year":2023,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; National Health and Medical Research Council; National Institutes of Health; Australian Research Council; University of Queensland","keywords":"Chemistry; Bivalent (engine); Potency; Native chemical ligation; Spider toxin; Selectivity; Peptide; Conotoxin; Sodium channel; Gating; Stereochemistry; Biophysics; Biochemistry; Sodium; In vitro; Receptor; Chemical synthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000283031,0.0002514391,0.0003745977,0.0001278569,0.00008942767,0.0003879766,0.0002392991,0.0002778902,0.001068706],"category_scores_gemma":[0.000241631,0.0001155765,0.0001857781,0.0001581874,0.0001787293,0.0002542153,0.0001868415,0.0005491737,0.0003751397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002460486,"about_ca_system_score_gemma":0.0001590802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002996709,"about_ca_topic_score_gemma":0.0004707885,"domain_scores_codex":[0.999718,0.00004022864,0.0000348617,0.00005794029,0.00008094718,0.00006792329],"domain_scores_gemma":[0.9998265,0.00004014891,0.00004492054,0.00001923808,0.00002763652,0.00004160231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005922652,0.00001746462,0.0002598512,0.00001420812,0.000005012179,0.00001188358,0.000008280048,0.00005439577,0.9983975,0.00002455715,0.00001502011,0.001132597],"study_design_scores_gemma":[0.0000104199,0.0006789312,0.003250457,0.000003030525,0.00002074606,0.000165372,0.00001830065,0.0004493549,0.9940605,0.00001680078,0.001322404,0.000003657747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964348,0.0008480039,0.001533545,0.00004162584,0.00001239001,0.00002480017,0.0001068632,0.00003331824,0.0009646867],"genre_scores_gemma":[0.9955798,0.0006753104,0.00183217,0.00007934636,0.000009626871,0.00002675159,0.0002326249,0.00001652049,0.001547884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001068706,"threshold_uncertainty_score":0.003575206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350359486011981,"score_gpt":0.2382136888138207,"score_spread":0.2247100939537009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}