{"id":"W4378978898","doi":"10.1093/ibd/izad089","title":"Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease","year":2023,"lang":"en","type":"review","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Cedars-Sinai Medical Center; National Institutes of Health; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Sexual dimorphism; Disease; Inflammatory bowel disease; Genome-wide association study; Biology; Genetic association; Sex characteristics; Genetics; Ulcerative colitis; Locus (genetics); Medicine; Genotype; Single-nucleotide polymorphism; Gene; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001856654,0.0004669836,0.0005946488,0.001704384,0.0002984998,0.0008110726,0.0004541609,0.0003893108,0.002874934],"category_scores_gemma":[0.002970973,0.0002050476,0.001679354,0.0017348,0.0004594331,0.0002137823,0.0004614484,0.0004650725,0.0001625379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001479122,"about_ca_system_score_gemma":0.0002130169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006154602,"about_ca_topic_score_gemma":0.001168146,"domain_scores_codex":[0.9988481,0.0003997766,0.0001154637,0.0003777501,0.0001758793,0.00008297609],"domain_scores_gemma":[0.9965689,0.001741566,0.001014167,0.0003036586,0.0001746719,0.0001969801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007092783,0.00002994376,0.9619784,0.0002069557,0.003351265,0.0007287787,0.0001397817,0.0003564427,0.01573589,0.0002176523,0.0002048214,0.01634083],"study_design_scores_gemma":[0.00003464201,0.0001159436,0.9939422,0.00002823502,0.001390583,0.001120568,0.00007345914,0.0005026026,0.001644735,0.0004262038,0.0007117525,0.000008958882],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.987815,0.007257993,0.002893441,0.0001451236,0.00002568245,0.00001783679,0.0009590062,0.00004668039,0.0008392734],"genre_scores_gemma":[0.9977667,0.0006395917,0.001006414,0.00006839229,0.00002548512,0.000009724318,0.0003102201,0.00001450969,0.0001590719],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002874934,"threshold_uncertainty_score":0.009819031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04613840118540682,"score_gpt":0.3282029287215009,"score_spread":0.2820645275360941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}