{"id":"W4378982159","doi":"10.1016/j.schres.2023.05.010","title":"Clozapine ultrarapid metabolism during weak induction probably exists but requires careful diagnosis. A literature review, five new cases and a proposed definition","year":2023,"lang":"en","type":"review","venue":"Schizophrenia Research","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Mental Health & Substance Use Services; University of British Columbia","funders":"","keywords":"Clozapine; Medicine; Therapeutic drug monitoring; Internal medicine; Randomized controlled trial; Pharmacology; Schizophrenia (object-oriented programming); Pharmacokinetics; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009611455,0.0009189865,0.002026506,0.003558099,0.0004226984,0.001372365,0.001012347,0.001141376,0.002216852],"category_scores_gemma":[0.002299801,0.0002908943,0.00163411,0.002820733,0.0008330918,0.001228046,0.000745436,0.001155135,0.0008154996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001055337,"about_ca_system_score_gemma":0.001966249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001821372,"about_ca_topic_score_gemma":0.003761518,"domain_scores_codex":[0.9994538,0.0001112396,0.0002060642,0.00007722914,0.0001173433,0.00003420528],"domain_scores_gemma":[0.9989622,0.0005761593,0.0002562359,0.00004500262,0.0001386806,0.00002162006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003550215,0.00005511563,0.001366738,0.08312732,0.0006047467,0.00394455,0.0002018447,0.0001366896,0.002063992,0.003853332,0.01067304,0.8936176],"study_design_scores_gemma":[0.000274417,0.0004293211,0.01184347,0.07339229,0.007380186,0.05557432,0.0007413464,0.0003998196,0.005026638,0.008833727,0.8359634,0.0001410398],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006092645,0.9974977,0.0002729568,0.0003429125,0.0001151229,0.00002522617,0.00005377022,0.000008261391,0.001074747],"genre_scores_gemma":[0.005653137,0.9928012,0.0005326367,0.0004108343,0.0001151161,0.0000314784,0.0001014433,0.000003129878,0.0003510389],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003558099,"threshold_uncertainty_score":0.007656991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1802706136538417,"score_gpt":0.4214146265134864,"score_spread":0.2411440128596447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}