{"id":"W4378983183","doi":"10.3390/molecules28114476","title":"Identification of Flavonoids from Scutellaria barbata D. Don as Inhibitors of HIV-1 and Cathepsin L Proteases and Their Structure–Activity Relationships","year":2023,"lang":"en","type":"article","venue":"Molecules","topic":"Flavonoids in Medical Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Health Commission of Guizhou Province","keywords":"Chemistry; Protease; Flavones; Luteolin; IC50; HIV-1 protease; Proteases; Stereochemistry; Traditional medicine; Flavonoid; Cathepsin; Wogonin; Biochemistry; Pharmacology; Enzyme; In vitro; Biology; Traditional Chinese medicine; Chromatography; Antioxidant; Medicine; Scutellaria baicalensis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008135469,0.0002952528,0.0002680682,0.000490285,0.0001723602,0.0001454208,0.0001197852,0.00020574,0.0006557457],"category_scores_gemma":[0.00006381459,0.0000795206,0.0003712865,0.0002432275,0.0001125052,0.0001683162,0.0001045915,0.0002843024,0.0001259903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001307284,"about_ca_system_score_gemma":0.0001240087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001120505,"about_ca_topic_score_gemma":0.00206565,"domain_scores_codex":[0.9999686,0.000004467563,0.000002038809,0.000008297373,0.00001003989,0.000006526069],"domain_scores_gemma":[0.9999692,0.000005484473,0.000008483086,0.000002276426,0.000007749444,0.000006841516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002754978,0.0001287534,0.0009348796,0.0002514242,0.00003450954,0.00008219948,0.00002037069,0.0002525257,0.9884243,0.0001012792,0.0001482814,0.009345837],"study_design_scores_gemma":[0.0002548786,0.001978319,0.0417299,0.00004680759,0.0002333428,0.0006891542,0.00008476462,0.002713844,0.9401023,0.0002137828,0.01191642,0.00003645855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843984,0.01000682,0.002354114,0.0002138361,0.00002328511,0.00008251384,0.0008544052,0.00005081795,0.002015886],"genre_scores_gemma":[0.9914589,0.00295131,0.002903503,0.0001509145,0.00001210368,0.00003428521,0.0008975022,0.000008175462,0.001583231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001120505,"threshold_uncertainty_score":0.002227962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02527215584557813,"score_gpt":0.2994821768634822,"score_spread":0.274210021017904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}