{"id":"W4378983183","doi":"10.3390/molecules28114476","title":"Identification of Flavonoids from Scutellaria barbata D. Don as Inhibitors of HIV-1 and Cathepsin L Proteases and Their Structure–Activity Relationships","year":2023,"lang":"en","type":"article","venue":"Molecules","topic":"Flavonoids in Medical Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Health Commission of Guizhou Province","keywords":"Chemistry; Protease; Flavones; Luteolin; IC50; HIV-1 protease; Proteases; Stereochemistry; Traditional medicine; Flavonoid; Cathepsin; Wogonin; Biochemistry; Pharmacology; Enzyme; In vitro; Biology; Traditional Chinese medicine; Chromatography; Antioxidant; Medicine; Scutellaria baicalensis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005110812,0.0001184529,0.0002589944,0.0001945891,0.00008025019,0.00001714288,0.00008761234,0.0001450679,0.00003565991],"category_scores_gemma":[0.003172997,0.00009390625,0.00003669105,0.0003373441,0.0003854247,0.00006934777,0.0001225992,0.0003027002,0.000006385248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002370684,"about_ca_system_score_gemma":0.0001092453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002908922,"about_ca_topic_score_gemma":0.0000246454,"domain_scores_codex":[0.9987159,0.0001882146,0.0003001568,0.0002819031,0.0003626022,0.0001512487],"domain_scores_gemma":[0.9988197,0.0004736579,0.0001212549,0.0003468364,0.0001068023,0.0001317254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001168172,0.00004741947,0.01854982,0.0001906775,0.00005051825,0.000006584069,0.0010526,0.000004428552,0.971857,0.0003082721,0.0003608219,0.007455083],"study_design_scores_gemma":[0.0004954142,0.0001140603,0.1918571,0.000167476,0.000043448,0.000002748134,0.0004170106,0.00240685,0.7994047,0.00493419,0.00007817605,0.00007878542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973347,0.0004047608,0.0005000837,0.0008363252,0.00004692419,0.000593335,0.0001672148,0.00003492078,0.00008177548],"genre_scores_gemma":[0.9991348,0.0001217266,0.0003956369,0.00001383525,0.00004957589,0.00001902253,0.00009558407,0.00001942246,0.0001503448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1733073,"threshold_uncertainty_score":0.3829386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02527215584557813,"score_gpt":0.2994821768634822,"score_spread":0.274210021017904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}