{"id":"W4378983268","doi":"10.1002/jbm4.10758","title":"A Phase I Randomized Trial of Once‐Daily Versus <scp>Twice‐Daily</scp> Recombinant Human Parathyroid Hormone (1‐84) for Hypoparathyroidism","year":2023,"lang":"en","type":"article","venue":"JBMR Plus","topic":"Thyroid and Parathyroid Surgery","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Takeda Pharmaceuticals U.S.A.","keywords":"Hypoparathyroidism; Parathyroid hormone; Recombinant DNA; Medicine; Hormone; Internal medicine; Endocrinology; Calcium; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00319316,0.0008112977,0.003341023,0.0007575669,0.0004095114,0.00008595044,0.0004482092,0.0005333925,0.00001647016],"category_scores_gemma":[0.003205844,0.0007005717,0.001686766,0.001278729,0.0004717912,0.0002679761,0.0001562305,0.0006243911,0.000446056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002271738,"about_ca_system_score_gemma":0.0006830347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009259663,"about_ca_topic_score_gemma":0.00001535111,"domain_scores_codex":[0.9939709,0.0004578219,0.002108246,0.001082631,0.0009911243,0.001389292],"domain_scores_gemma":[0.9922967,0.004539708,0.0009234977,0.001224245,0.0003837603,0.0006321098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5687531,0.001525511,0.000002788759,0.00005491594,0.0005380411,0.0001695666,0.001488537,0.00001951886,0.1398115,0.00141874,0.2858357,0.0003820971],"study_design_scores_gemma":[0.9355609,0.01079707,0.00008502118,0.00005189076,0.0009348486,0.00003713926,0.0008684858,0.001907403,0.008697923,0.0009426911,0.03975661,0.0003600037],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751762,0.006527,0.0002263252,0.0004616643,0.002830122,0.006009743,0.0001983161,0.0005737309,0.007996899],"genre_scores_gemma":[0.9734412,0.001772846,0.0004659774,0.0002031187,0.001821807,0.001878278,0.001061376,0.0002041736,0.01915125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3668078,"threshold_uncertainty_score":0.9995446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05786591201678766,"score_gpt":0.3530365711355228,"score_spread":0.2951706591187351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}