{"id":"W4379010264","doi":"10.3389/fgeed.2023.1196697","title":"Similar deamination activities but different phenotypic outcomes induced by APOBEC3 enzymes in breast epithelial cells","year":2023,"lang":"en","type":"article","venue":"Frontiers in Genome Editing","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"Deamination; In vitro; Biology; Enzyme; Biochemistry; Cell culture; DNA; Cell; Molecular biology; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723727,0.0002357837,0.0002369037,0.0002328633,0.0001945677,0.0003746745,0.0001268032,0.000311442,0.0008064509],"category_scores_gemma":[0.0002073702,0.0001462207,0.0002996701,0.0003011703,0.0001529784,0.0001773647,0.0001730431,0.000702788,0.0004160905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002756402,"about_ca_system_score_gemma":0.0001777317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00217318,"about_ca_topic_score_gemma":0.002348857,"domain_scores_codex":[0.9996949,0.00004105949,0.0000391752,0.00006360491,0.00009775543,0.0000635461],"domain_scores_gemma":[0.9997692,0.00005043154,0.0000307857,0.00004785137,0.00006679322,0.00003505893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003400355,0.00001194767,0.0002583755,0.00001747959,0.000003733194,0.00003360743,0.00002612618,0.00001578001,0.9990589,0.00002310807,0.00002039817,0.000496538],"study_design_scores_gemma":[0.000006079839,0.0002175646,0.01480767,0.00000500321,0.00001870094,0.0003750713,0.000129289,0.0003809094,0.9819405,0.00003946171,0.002071024,0.000008664961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911589,0.001500776,0.003922919,0.00009675763,0.00003715236,0.00004769867,0.001179733,0.00009730731,0.001958829],"genre_scores_gemma":[0.9870974,0.0009254426,0.004384794,0.0001165236,0.000007543458,0.00008983261,0.002549187,0.00003065967,0.004798531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00217318,"threshold_uncertainty_score":0.004321098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01104844606458755,"score_gpt":0.2550550317836941,"score_spread":0.2440065857191066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}