{"id":"W4379010264","doi":"10.3389/fgeed.2023.1196697","title":"Similar deamination activities but different phenotypic outcomes induced by APOBEC3 enzymes in breast epithelial cells","year":2023,"lang":"en","type":"article","venue":"Frontiers in Genome Editing","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"Deamination; In vitro; Biology; Enzyme; Biochemistry; Cell culture; DNA; Cell; Molecular biology; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004904657,0.0002477467,0.0002963956,0.0003413272,0.00009470083,0.00004249756,0.0003130843,0.000205102,0.0000204915],"category_scores_gemma":[0.0000666358,0.0002517438,0.00008386699,0.000287218,0.00007138993,0.00001411175,0.000157044,0.0002659598,0.000009995711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001431585,"about_ca_system_score_gemma":0.00006618027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004104029,"about_ca_topic_score_gemma":0.0001243048,"domain_scores_codex":[0.9981131,0.0002048078,0.000310988,0.0004639314,0.000304293,0.0006028935],"domain_scores_gemma":[0.999467,0.00004206429,0.00009657713,0.0002804203,0.00003433156,0.00007958293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002554925,0.00007918203,0.02037909,0.00003068248,0.000049032,0.000006969499,0.0002912252,0.0002214895,0.9669976,0.000003247585,0.002220553,0.009465381],"study_design_scores_gemma":[0.001396143,0.0003665988,0.03462471,0.00002214094,0.000008118956,0.000001336549,0.002149922,0.0007222054,0.9589747,0.0001491723,0.001183257,0.0004017392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970136,0.0005504101,0.0004496355,0.0002950018,0.001073297,0.00029416,0.0001961239,0.00003347612,0.00009424295],"genre_scores_gemma":[0.9978638,0.0002132136,0.0001623371,0.00008830382,0.0006451524,0.0000861411,0.0002976127,0.00005370638,0.0005896977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01424562,"threshold_uncertainty_score":0.9999935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01104844606458755,"score_gpt":0.2550550317836941,"score_spread":0.2440065857191066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}