{"id":"W4379013481","doi":"10.1016/j.critrevonc.2023.104041","title":"Evidence-based mechanisms of synergy with IMiD agent-based combinations in multiple myeloma","year":2023,"lang":"en","type":"review","venue":"Critical Reviews in Oncology/Hematology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"Cumming School of Medicine, University of Calgary; Bristol-Myers Squibb","keywords":"Pomalidomide; Lenalidomide; Medicine; Multiple myeloma; Thalidomide; Combination therapy; Drug; Mechanism of action; Pharmacology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001295431,0.0008188683,0.002485709,0.001595001,0.0001782761,0.001278031,0.001077608,0.001043363,0.004432454],"category_scores_gemma":[0.002200247,0.0002967683,0.001577269,0.001662116,0.0003353447,0.0009188386,0.0005936872,0.001550485,0.0008124901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005991859,"about_ca_system_score_gemma":0.001184517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009176903,"about_ca_topic_score_gemma":0.001992367,"domain_scores_codex":[0.9995864,0.0001255775,0.00008609825,0.0000515774,0.0001201197,0.0000302359],"domain_scores_gemma":[0.9990257,0.000661292,0.0001633066,0.00001591694,0.0001098016,0.00002404916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006441178,0.0001052281,0.0001925969,0.09583666,0.001398437,0.0001371662,0.00004296423,0.0005819425,0.001244044,0.002209048,0.01394142,0.8836665],"study_design_scores_gemma":[0.001008246,0.001307182,0.003236967,0.07454861,0.008802564,0.001719802,0.0001324892,0.0004493976,0.001684421,0.004917379,0.9021153,0.00007766039],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007991688,0.9994959,0.00004113164,0.00008965455,0.00005383997,0.000006693266,0.00001483948,0.000002076018,0.0002159617],"genre_scores_gemma":[0.001102491,0.9983942,0.0001500985,0.0001499306,0.0000741461,0.000009850787,0.00002166898,6.566218e-7,0.00009689786],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004432454,"threshold_uncertainty_score":0.01482797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2681742536432019,"score_gpt":0.4716844319718877,"score_spread":0.2035101783286858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}