{"id":"W4379014572","doi":"10.1101/2023.05.31.543159","title":"Combinatorial Regimens Augment Drug Monotherapy for SARS-CoV-2 Clearance in Mice","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Héma-Québec; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; National Institutes of Health; Drugs for Neglected Diseases initiative; Wellcome Trust","keywords":"Favipiravir; Virology; Virus; Neutralizing antibody; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Medicine; Protease; Pharmacology; Drug; Coronavirus disease 2019 (COVID-19); Immunology; Biology; Enzyme; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000255441,0.0006602108,0.0006850959,0.0006503881,0.0002019397,0.0005865884,0.0003776528,0.0005791385,0.002602945],"category_scores_gemma":[0.0001253159,0.0002202871,0.0004503136,0.000274326,0.0003384365,0.0004755156,0.0002225169,0.001666363,0.0008146371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003628643,"about_ca_system_score_gemma":0.0004257119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005341229,"about_ca_topic_score_gemma":0.001110537,"domain_scores_codex":[0.9997091,0.0000399514,0.00001822391,0.00006920582,0.00008113821,0.00008231722],"domain_scores_gemma":[0.9998581,0.00001444978,0.00003907018,0.00001954742,0.00001258038,0.00005608593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001936265,0.0015155,0.0003403738,0.0001156912,0.00004702116,0.00008483034,0.00004908976,0.0008652264,0.9765609,0.0007956804,0.001262768,0.01642672],"study_design_scores_gemma":[0.0003657239,0.007103251,0.001629633,0.00001538975,0.00007621515,0.0002080145,0.00003534585,0.003515362,0.9763857,0.0002662711,0.01038098,0.00001809495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736746,0.00250441,0.009991419,0.0008125224,0.0004023091,0.0003222195,0.002380297,0.0008988915,0.009013351],"genre_scores_gemma":[0.9709321,0.001679427,0.01383451,0.0004344805,0.0001340975,0.0004476359,0.001695164,0.0001978783,0.01064459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002602945,"threshold_uncertainty_score":0.008707702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0446566240616419,"score_gpt":0.3176516593158092,"score_spread":0.2729950352541673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}