{"id":"W4379034371","doi":"10.2139/ssrn.4463537","title":"Tracking Coreceptor Switch of the Transmitted/Founder HIV-1 Identifies Co-Evolution of HIV-1 Antigenicity, Coreceptor Usage and CD4 Subset Targeting: The RV217 Acute Infection Cohort Study","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Antigenicity; Human immunodeficiency virus (HIV); Virology; Biology; Tracking (education); Cohort; Computational biology; Medicine; Genetics; Antibody; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007288776,0.0006011887,0.0004836766,0.0003369441,0.0006221006,0.001168186,0.0006771206,0.0007545908,0.00251695],"category_scores_gemma":[0.001356564,0.0004961799,0.000617318,0.0005065867,0.0003471043,0.0006693964,0.0007506927,0.0009872322,0.001260394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002927612,"about_ca_system_score_gemma":0.0002946564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002998258,"about_ca_topic_score_gemma":0.003446975,"domain_scores_codex":[0.9995703,0.00009860272,0.0000247054,0.000148614,0.00006314282,0.00009468678],"domain_scores_gemma":[0.9992907,0.00006918899,0.0001499492,0.000238661,0.00008511456,0.0001663264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001666122,0.0001876028,0.9907699,0.00001539931,0.00035059,0.0003072221,0.0003014701,0.00007890446,0.00182639,0.0001092909,0.001204109,0.003183036],"study_design_scores_gemma":[0.00006953011,0.0005140819,0.9961336,0.00001257965,0.0002182603,0.0009621343,0.0005006779,0.0002481343,0.0002780162,0.0001118542,0.0009358981,0.00001538638],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985677,0.00007906675,0.00007395149,0.00003170892,0.000009796547,0.000007451639,0.0009404702,0.000003636439,0.0002861698],"genre_scores_gemma":[0.9972473,0.00008989774,0.00009484505,0.00004644796,0.00002300806,0.00001119488,0.001722316,0.00001393,0.0007510174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002998258,"threshold_uncertainty_score":0.00842005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0196548250813461,"score_gpt":0.2889625147605883,"score_spread":0.2693076896792422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}