{"id":"W4379053203","doi":"10.3389/fphys.2023.1166125","title":"Lost in traffic: consequences of altered palmitoylation in neurodegeneration","year":2023,"lang":"en","type":"review","venue":"Frontiers in Physiology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; ALS Society of Canada","keywords":"Palmitoylation; Proteostasis; Neurodegeneration; Cell biology; Biology; Autophagy; Ubiquitin; Transport protein; Biochemistry; Chemistry; Cysteine; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003069923,0.0007636186,0.0006993269,0.0006524244,0.0007142421,0.0006559963,0.0004619901,0.001493747,0.003255733],"category_scores_gemma":[0.0003743052,0.0002302251,0.0006439586,0.0004604727,0.0007292382,0.0008214798,0.001011607,0.0015985,0.0009968665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005516694,"about_ca_system_score_gemma":0.0004089251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008979954,"about_ca_topic_score_gemma":0.0005179842,"domain_scores_codex":[0.9997966,0.00002971229,0.00002037437,0.00005434969,0.00004398162,0.00005500823],"domain_scores_gemma":[0.9996982,0.00001733101,0.00009393084,0.00002569744,0.00004202562,0.0001228694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005562037,0.0005723745,0.007411405,0.0004268456,0.0002085577,0.01458902,0.0002779273,0.0008590405,0.9474036,0.003223212,0.00268576,0.01678026],"study_design_scores_gemma":[0.0006140136,0.003703859,0.2046392,0.0003631795,0.0009233863,0.06700239,0.00145958,0.009253791,0.6573533,0.0253629,0.02913613,0.0001881933],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9824759,0.008724789,0.003118068,0.001617035,0.0004443338,0.00004219314,0.0009054525,0.0002572836,0.002414925],"genre_scores_gemma":[0.9910389,0.004036523,0.0007401094,0.0004793678,0.00008372126,0.00004670829,0.0005587311,0.00006334619,0.002952523],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003255733,"threshold_uncertainty_score":0.0108915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07990862688211303,"score_gpt":0.3715965521984428,"score_spread":0.2916879253163298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}