{"id":"W4379053486","doi":"10.1172/jci.insight.167546","title":"Natural history of retinitis pigmentosa based on genotype, vitamin A/E supplementation, and an electroretinogram biomarker","year":2023,"lang":"en","type":"article","venue":"JCI Insight","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Eye Institute; Foundation Fighting Blindness","keywords":"Retinitis pigmentosa; Medicine; Biomarker; Vitamin E; Randomized controlled trial; Internal medicine; Vitamin; Clinical trial; Oncology; Ophthalmology; Biology; Genetics; Retinal; Antioxidant; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001877611,0.0003927677,0.0007769053,0.0004607216,0.0002831363,0.0004288982,0.0003634533,0.0006174245,0.002434533],"category_scores_gemma":[0.002252143,0.0001582665,0.0008683181,0.0004117662,0.0003570615,0.0003638418,0.0001863096,0.0005061945,0.0001666896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003486408,"about_ca_system_score_gemma":0.0003909956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007798051,"about_ca_topic_score_gemma":0.001382485,"domain_scores_codex":[0.9993669,0.0002613542,0.00006040391,0.0001660434,0.00009346302,0.00005174451],"domain_scores_gemma":[0.9981149,0.0006906407,0.0007494761,0.0001055442,0.00008936281,0.000250045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2479743,0.001163856,0.6950566,0.0005588545,0.002629619,0.0002399326,0.00006486775,0.0008359586,0.003099106,0.0001687396,0.0009741178,0.04723405],"study_design_scores_gemma":[0.008599003,0.01295857,0.9693356,0.0001951732,0.002779722,0.0007088472,0.00005772549,0.001637157,0.001591724,0.0007339225,0.001359213,0.00004319664],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991563,0.005535319,0.0002244422,0.0002519838,0.00004348572,0.0001818344,0.0009249325,0.00001106476,0.001263907],"genre_scores_gemma":[0.9977222,0.0005054206,0.0003442479,0.0001087362,0.00003835184,0.0001436314,0.0006188613,0.000002044342,0.0005165598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002434533,"threshold_uncertainty_score":0.009929836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01248174120403616,"score_gpt":0.2570167205239161,"score_spread":0.2445349793198799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}