{"id":"W4379053859","doi":"10.1186/s12885-023-10993-1","title":"Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling","year":2023,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Cancer Research Society","keywords":"Receptor; Cancer research; Signal transduction; Cell growth; Biology; Breast cancer; Estrogen receptor; Neuropeptide Y receptor; Cell migration; Cancer cell; Hypoxia (environmental); MAPK/ERK pathway; Cell biology; Cancer; Medicine; Endocrinology; Internal medicine; Cell; Neuropeptide; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009066067,0.0002089414,0.0002337,0.0001073007,0.000108669,0.000134095,0.0001615854,0.0001932441,0.002031583],"category_scores_gemma":[0.00007092229,0.00006729627,0.0001811365,0.00006854983,0.0001160481,0.0001073968,0.00009954105,0.0003888914,0.0002875356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002301178,"about_ca_system_score_gemma":0.0001954737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008080194,"about_ca_topic_score_gemma":0.001721875,"domain_scores_codex":[0.9999119,0.00001062988,0.000007032222,0.00001170438,0.00002287323,0.00003587358],"domain_scores_gemma":[0.9999554,0.000006879473,0.00001179395,0.000003808231,0.000005689859,0.00001637484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004300135,0.0001041379,0.0002157774,0.0001004102,0.00001108261,0.00002768939,0.00001675153,0.00007262536,0.9961506,0.00004737311,0.0001615716,0.002661989],"study_design_scores_gemma":[0.00005645819,0.002351193,0.01004594,0.00001613482,0.0000469335,0.0001871539,0.0000885394,0.0008871445,0.9821342,0.0000254949,0.004155305,0.000005622572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943224,0.003135683,0.0006458354,0.0001531484,0.00003927049,0.00001766077,0.0002622335,0.00004226422,0.001381497],"genre_scores_gemma":[0.9938504,0.002101854,0.0009502269,0.0001046455,0.00001313292,0.00005075286,0.0005228911,0.00001005679,0.002396028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002031583,"threshold_uncertainty_score":0.00679636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05258700588910874,"score_gpt":0.3088110630838486,"score_spread":0.2562240571947399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}