{"id":"W4379053944","doi":"10.1016/j.celrep.2023.112578","title":"Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Bone Tumor Diagnosis and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Isocitrate dehydrogenase; Chondrosarcoma; IDH1; Mutant; IDH2; Biology; Somatic cell; Glycogen; Malignant transformation; Cancer research; Gene; Enzyme; Genetics; Biochemistry; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005693125,0.0001817289,0.0001268024,0.0001933049,0.0001017725,0.0001810526,0.0001414507,0.0001438342,0.0008445281],"category_scores_gemma":[0.00006641944,0.0001054509,0.0001241939,0.0000765385,0.0001617524,0.00007504262,0.0001239389,0.0002364999,0.0002056596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002799218,"about_ca_system_score_gemma":0.0001933958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008761295,"about_ca_topic_score_gemma":0.001556767,"domain_scores_codex":[0.9999474,0.000005884767,0.000004348865,0.000008984132,0.00001736173,0.00001602236],"domain_scores_gemma":[0.999938,0.000006683812,0.00001731697,0.000003916375,0.000006053294,0.0000279703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001109747,0.00001695148,0.0005578531,0.00001571985,0.000002231229,0.0001061694,0.00000983348,0.00003544139,0.9981295,0.00009729707,0.00005325682,0.0008646204],"study_design_scores_gemma":[0.00001814179,0.0001859832,0.02266412,0.000005178136,0.00001076996,0.0005092794,0.00004602551,0.0007159539,0.9736941,0.00008901785,0.002056556,0.000004866033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955122,0.001529462,0.001234511,0.00008533502,0.00002131393,0.00001078086,0.0002298612,0.00006452849,0.001311917],"genre_scores_gemma":[0.9966094,0.0006802454,0.000701986,0.00004084027,0.000004192078,0.00001260105,0.0001898976,0.00001112734,0.001749703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008761295,"threshold_uncertainty_score":0.00282526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01656762475020043,"score_gpt":0.2399108951043319,"score_spread":0.2233432703541315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}