{"id":"W4379053944","doi":"10.1016/j.celrep.2023.112578","title":"Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Bone Tumor Diagnosis and Treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Isocitrate dehydrogenase; Chondrosarcoma; IDH1; Mutant; IDH2; Biology; Somatic cell; Glycogen; Malignant transformation; Cancer research; Gene; Enzyme; Genetics; Biochemistry; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001857782,0.00020884,0.000370218,0.0001554605,0.0001102604,0.00004242415,0.0000502369,0.00006741978,0.0001291017],"category_scores_gemma":[0.00003885648,0.0001671928,0.0001023306,0.0003355914,0.00001504388,0.000117311,0.00008316998,0.00006766892,0.0007428332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001035298,"about_ca_system_score_gemma":0.00009320889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002149764,"about_ca_topic_score_gemma":0.000027752,"domain_scores_codex":[0.9981943,0.00001946819,0.0005911178,0.0004061258,0.0004213683,0.0003675871],"domain_scores_gemma":[0.9989308,0.0000281418,0.0001871238,0.0004898483,0.00007981831,0.0002843449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002063701,0.0008543854,0.1058623,0.0001731049,0.0002661368,0.05470191,0.0100703,0.00003889034,0.7977353,0.00003017548,0.01152109,0.01853998],"study_design_scores_gemma":[0.0004700314,0.00005368578,0.2746953,0.0001008954,0.0001180075,0.0002656117,0.00007857408,0.00001305073,0.6977234,0.0001127735,0.02621523,0.0001534604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965297,0.0004691365,0.00001802291,0.0002553144,0.0004044081,0.0006673747,0.00001797737,0.0001951161,0.001442955],"genre_scores_gemma":[0.9948845,0.00003951099,0.001005042,0.0001485712,0.0000780482,0.0001639992,0.0004617077,0.0000388202,0.003179812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1688329,"threshold_uncertainty_score":0.9547866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01656762475020043,"score_gpt":0.2399108951043319,"score_spread":0.2233432703541315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}