{"id":"W4379055582","doi":"10.3390/fermentation9060534","title":"Production of Glyoxylate from Glucose in Engineered Escherichia coli","year":2023,"lang":"en","type":"article","venue":"Fermentation","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Brain Research Centre; Yale University","keywords":"Glyoxylate cycle; Malate synthase; Isocitrate lyase; Escherichia coli; Biochemistry; Citrate synthase; Biology; Metabolic engineering; Glyoxysome; Chemistry; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473269,0.0006953093,0.0003639962,0.0002229627,0.0001254685,0.0005122213,0.0002730862,0.0003007324,0.0002299531],"category_scores_gemma":[0.0001274377,0.0001427182,0.0002961016,0.0003055129,0.000152337,0.0001888574,0.000363851,0.000526064,0.0002645202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003053434,"about_ca_system_score_gemma":0.0002162981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00125343,"about_ca_topic_score_gemma":0.001546547,"domain_scores_codex":[0.9998134,0.0000327283,0.00001969868,0.00003331359,0.00006745085,0.00003344448],"domain_scores_gemma":[0.9999425,0.000006674071,0.00001611151,0.000008627308,0.00001098137,0.00001509845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003452382,0.00002385903,0.0002103117,0.00002815633,0.000006094741,0.00006740838,0.000006501618,0.000164744,0.9984286,0.00004640521,0.00001786407,0.0009655124],"study_design_scores_gemma":[0.000008656538,0.000101507,0.001079409,0.000005648921,0.00001663452,0.0001139396,0.00002168578,0.001546648,0.995778,0.00002520832,0.001295714,0.000007001319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755485,0.0007423587,0.02122354,0.0001533033,0.00007105675,0.0000676021,0.0005110801,0.0002387231,0.001443852],"genre_scores_gemma":[0.9713622,0.0008914845,0.02402059,0.00006248825,0.000009591442,0.00003754657,0.001020572,0.00005959766,0.002535967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00125343,"threshold_uncertainty_score":0.002492249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008111619450324214,"score_gpt":0.2317011901428276,"score_spread":0.2235895706925033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}