{"id":"W4379055968","doi":"10.1038/s41598-023-35716-1","title":"Protocol development to further differentiate and transition stem cell-derived pancreatic progenitors from a monolayer into endocrine cells in suspension culture","year":2023,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; Canada's Michael Smith Genome Sciences Centre; Stemcell Technologies; University of British Columbia","funders":"Breakthrough T1D Canada; Mitacs; Canadian Institutes of Health Research; University of British Columbia; Michael Smith Health Research BC; Juvenile Diabetes Research Foundation Canada","keywords":"Progenitor cell; Enteroendocrine cell; Endocrine system; Induced pluripotent stem cell; Cell biology; Cell culture; Stem cell; Biology; Endocrinology; Hormone; Embryonic stem cell; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001677911,0.001157393,0.001052356,0.001479443,0.0009168757,0.0009013291,0.001144794,0.0007503786,0.007723019],"category_scores_gemma":[0.001145518,0.0007731392,0.001069939,0.0009326102,0.0005616126,0.0007039852,0.0006941609,0.002035706,0.007869787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000355073,"about_ca_system_score_gemma":0.001446545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008167489,"about_ca_topic_score_gemma":0.002010149,"domain_scores_codex":[0.9985989,0.0001827085,0.0003322763,0.0002365682,0.0005011188,0.0001483937],"domain_scores_gemma":[0.9989166,0.0002307097,0.0001033641,0.0002222784,0.00039931,0.0001278177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000102135,0.0001445363,0.0003768,0.0005300611,0.00001946888,0.0003531911,0.0001838005,0.0003601779,0.9799253,0.0009563998,0.001944267,0.01510388],"study_design_scores_gemma":[0.00008839952,0.0006903039,0.001917134,0.0001389929,0.0001210699,0.0009777527,0.0001132266,0.002385352,0.905102,0.0004829943,0.0879109,0.0000719506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1266116,0.004191641,0.8173257,0.0005319172,0.001330735,0.01821097,0.007035506,0.004887698,0.01987421],"genre_scores_gemma":[0.09275202,0.007811494,0.8157673,0.0005394428,0.0002288897,0.0430674,0.01423027,0.001094062,0.02450905],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.007723019,"threshold_uncertainty_score":0.02583611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01711832251620098,"score_gpt":0.2587442818734468,"score_spread":0.2416259593572458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}