{"id":"W4379057683","doi":"10.1038/s41467-023-37979-8","title":"The blood proteome of imminent lung cancer diagnosis","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Cancer Institute; Faculty of Medicine and Health, University of Sydney; NIHR Imperial Biomedical Research Centre; Rijksinstituut voor Volksgezondheid en Milieu; Norwegian Institute of Public Health; World Cancer Research Fund; Medical Research Council; University of Melbourne; Cancer Council Victoria; School of Medicine, Vanderbilt University; Associazione Italiana per la Ricerca sul Cancro; School of Medicine, New York University; National Institutes of Health; Mutuelle Générale de l'Education Nationale; Université Paris-Saclay; National Health and Medical Research Council; Centers for Disease Control and Prevention; Institut National Du Cancer; York University; Universidad de Navarra; Vetenskapsrådet; Fondation ARC pour la Recherche sur le Cancer; School of Public Health, Imperial College London; University of Oxford; Deutsche Krebshilfe; Imperial College London; University of Toronto; Monash University; Institut National de la Santé et de la Recherche Médicale; National Institute for Health and Care Research; Singapore Institute for Clinical Sciences; Bundesministerium für Bildung und Forschung; Cancerfonden; Institut Gustave-Roussy; Norges Teknisk-Naturvitenskapelige Universitet; Ligue Contre le Cancer; Vanderbilt University Medical Center; Deutsches Krebsforschungszentrum; Instituto de Salud Carlos III; Helse Midt-Norge; Cancer Research UK; National University of Singapore; Brigham and Women's Hospital; Emory University; Johns Hopkins Bloomberg School of Public Health; Vanderbilt University; World Health Organization; University of Pittsburgh; Johns Hopkins University; Centre International de Recherche sur le Cancer; Umeå Universitet; European Commission","keywords":"Lung cancer; Metastasis; Cancer; Medicine; Angiogenesis; Chemokine; Lung; Internal medicine; Odds ratio; Oncology; Proteome; Biomarker; Prospective cohort study; Inflammation; Cancer research; Immunology; Pathology; Biology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005472701,0.0002230566,0.0003480981,0.000746418,0.0002597126,0.0009131495,0.0001726352,0.0004351137,0.001112613],"category_scores_gemma":[0.001244587,0.0002136784,0.0002150671,0.0009503156,0.0002426279,0.0002387321,0.000397893,0.0004362417,0.0004147973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003084604,"about_ca_system_score_gemma":0.000246269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002226445,"about_ca_topic_score_gemma":0.001564208,"domain_scores_codex":[0.9996723,0.0001009302,0.00002218645,0.00007957716,0.00008216289,0.00004297777],"domain_scores_gemma":[0.9992856,0.0001382024,0.0003317244,0.00005429173,0.0001038742,0.00008628175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001184827,0.00005582844,0.912563,0.0001156321,0.0002228502,0.0005344262,0.0002127303,0.0002672815,0.07516747,0.000213928,0.000824311,0.008637862],"study_design_scores_gemma":[0.000009240531,0.00008302704,0.9909679,0.00001144261,0.000047155,0.0005876334,0.00009035866,0.0006752523,0.006097811,0.0002216867,0.001202198,0.000006196573],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955907,0.002067896,0.0005315508,0.0001586451,0.00002044227,0.000005359702,0.001037575,0.00001501352,0.0005729058],"genre_scores_gemma":[0.9979977,0.0003812756,0.0003661483,0.00007653883,0.00001678259,0.000003851843,0.0007679692,0.000003656572,0.0003860524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002226445,"threshold_uncertainty_score":0.004427016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194463926310613,"score_gpt":0.3139038823157186,"score_spread":0.3019592430526125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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