{"id":"W4379093552","doi":"10.1007/s11248-023-00351-z","title":"A novel approach to achieving more efficient production of the mature form of human IL-37 in plants","year":2023,"lang":"en","type":"article","venue":"Transgenic Research","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Biology; Signal peptide; Fusion protein; Computational biology; Protease; Gene; Cell biology; Peptide sequence; Genetics; Biochemistry; Recombinant DNA; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006963078,0.0000790046,0.0001191569,0.0001070759,0.00009140158,0.000005486821,0.0003915174,0.00009392257,0.000002071094],"category_scores_gemma":[0.00002747758,0.00005766881,0.00007271719,0.0006643307,0.0001099247,0.000001756986,0.00006132274,0.0001961494,0.00000224134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000112362,"about_ca_system_score_gemma":0.00008195988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000578531,"about_ca_topic_score_gemma":0.0001607658,"domain_scores_codex":[0.9988309,0.00004586443,0.0002189826,0.0002885436,0.0003367948,0.0002788852],"domain_scores_gemma":[0.9994254,0.00001386053,0.00002842698,0.0004267578,0.00006257403,0.00004304728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005900609,0.0001872385,0.0005495899,0.00008979034,0.00001704584,9.413694e-8,0.0009532378,0.001335969,0.9958529,0.0002178248,0.0003506303,0.0003866764],"study_design_scores_gemma":[0.0005523799,0.0001109261,0.1788583,0.00007743511,0.000007722321,0.000006325004,0.0008206681,0.0002155283,0.8176912,0.00004539723,0.001493113,0.0001209842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978415,0.00005593009,0.0002744145,0.0004632525,0.00003015037,0.0006839194,0.000127397,0.000006758949,0.0005166496],"genre_scores_gemma":[0.9991314,0.00005381283,0.0001504987,0.000008162662,0.0000387857,0.00007912864,0.00007398999,0.00001308012,0.000451098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1783088,"threshold_uncertainty_score":0.2351666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0767832885240488,"score_gpt":0.3661838118148388,"score_spread":0.28940052329079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}