{"id":"W4379094559","doi":"10.1053/j.gastro.2023.05.032","title":"Gut Microbiome Composition Is Associated With Future Onset of Crohn’s Disease in Healthy First-Degree Relatives","year":2023,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":192,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; Queen's University; University of Ottawa; BC Children's Hospital; University of Alberta; Izaak Walton Killam Health Centre; Hôpital Maisonneuve-Rosemont; University of Manitoba; University of Calgary; Mount Sinai Hospital; Princess Margaret Cancer Centre; Public Health Ontario; Hospital for Sick Children; Dalhousie University; Centre Hospitalier Universitaire Sainte-Justine; McMaster University; Children's Hospital of Eastern Ontario; Population Health Research Institute; University Health Network; Western University; University of Toronto","funders":"Crohn's and Colitis Canada; Ferring Pharmaceuticals; Canada Research Chairs; Canadian Association of Gastroenterology; National GEM Consortium; Canadian Institutes of Health Research; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Microbiome; Roseburia; Cohort; Metagenomics; Gut flora; Disease; Ruminococcus; Biology; Crohn's disease; Immunology; Inflammatory bowel disease; Medicine; Internal medicine; Bioinformatics; Genetics; Lactobacillus; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002724581,0.0005386688,0.0005640693,0.0008484016,0.0007461207,0.0007067312,0.0003256522,0.0008575133,0.0040464],"category_scores_gemma":[0.001869636,0.0004468256,0.0007200214,0.0009180016,0.000362009,0.000461561,0.0004087609,0.001003663,0.0004538149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002494669,"about_ca_system_score_gemma":0.0001837352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003825123,"about_ca_topic_score_gemma":0.003169899,"domain_scores_codex":[0.9996777,0.00007664179,0.00002545001,0.00009814384,0.00003868409,0.00008330431],"domain_scores_gemma":[0.9986129,0.0002533179,0.0005298122,0.0001029059,0.00007211667,0.0004288501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006295326,0.00008354639,0.9944059,0.0000136708,0.00009808243,0.001064041,0.0001555823,0.0000348428,0.002123342,0.00003095595,0.00009989795,0.001260641],"study_design_scores_gemma":[0.000005352008,0.0001141319,0.9979061,0.00000580015,0.00004621525,0.001411817,0.0001820004,0.00008147871,0.0001145522,0.00003237453,0.00009551643,0.000004714428],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990467,0.0002734417,0.00004559531,0.00005915628,0.00001352115,0.000001352704,0.0001026002,0.000004893942,0.0004526733],"genre_scores_gemma":[0.9993871,0.00009893804,0.00005544202,0.0000226931,0.00001358143,0.000001318469,0.00008290489,0.000002770341,0.0003352544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0040464,"threshold_uncertainty_score":0.01353657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200359714629292,"score_gpt":0.2513198196267808,"score_spread":0.2393162224804879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}