{"id":"W4379094806","doi":"10.1007/s40265-023-01882-9","title":"Targeting IL-23 for IBD: Rationale and Progress to Date","year":2023,"lang":"en","type":"review","venue":"Drugs","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Western University","funders":"","keywords":"Medicine; Ustekinumab; Ulcerative colitis; Interleukin 23; Inflammatory bowel disease; Crohn's disease; Psoriasis; Disease; Immunology; Clinical trial; Internal medicine; Gastroenterology; Immune system; Interleukin 17; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002576456,0.0002642424,0.0007625739,0.0001296269,0.0001808266,0.00002262807,0.0001495399,0.0002858509,0.00004114837],"category_scores_gemma":[0.00005786286,0.0002070578,0.0002179647,0.0001466219,0.0000435743,0.0000305655,0.00009381342,0.000090723,0.00127062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001943842,"about_ca_system_score_gemma":0.00008223098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000364334,"about_ca_topic_score_gemma":0.00000229856,"domain_scores_codex":[0.9988837,0.0001142594,0.0003040189,0.0003914942,0.00002260205,0.0002839314],"domain_scores_gemma":[0.9993008,0.000326604,0.0001370784,0.0001728755,0.00003772749,0.00002493037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000176842,0.0000259081,0.000003569126,0.002748382,0.0006332298,0.0000028094,0.0002660688,8.984819e-8,0.00001768526,0.0002722093,0.01870425,0.9773081],"study_design_scores_gemma":[0.0003262715,0.00004565091,0.000002165619,0.001085635,0.0006791825,0.0000100436,0.0000484854,2.225266e-7,0.00003413616,0.00002786103,0.9975251,0.0002152533],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005690935,0.9959768,0.00001276689,0.000074879,0.0008003207,0.001640264,0.001250955,0.00009185705,0.0000952365],"genre_scores_gemma":[0.000003866558,0.9770507,0.0003630182,0.00002963683,0.0001638895,0.001485178,0.007584984,0.00005131499,0.01326738],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9788209,"threshold_uncertainty_score":0.999507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05452225443549843,"score_gpt":0.3243609393276801,"score_spread":0.2698386848921817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}