{"id":"W4379094806","doi":"10.1007/s40265-023-01882-9","title":"Targeting IL-23 for IBD: Rationale and Progress to Date","year":2023,"lang":"en","type":"review","venue":"Drugs","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Western University","funders":"","keywords":"Medicine; Ustekinumab; Ulcerative colitis; Interleukin 23; Inflammatory bowel disease; Crohn's disease; Psoriasis; Disease; Immunology; Clinical trial; Internal medicine; Gastroenterology; Immune system; Interleukin 17; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009604805,0.001090491,0.001973039,0.001354433,0.00022572,0.001372117,0.0009059302,0.001272288,0.003744789],"category_scores_gemma":[0.001080134,0.0002964858,0.0006309529,0.001248301,0.000516769,0.001250735,0.0006846788,0.003390742,0.002054519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005093674,"about_ca_system_score_gemma":0.001079321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006978189,"about_ca_topic_score_gemma":0.001867172,"domain_scores_codex":[0.9997924,0.00004176328,0.00002839774,0.0000374822,0.00007098301,0.00002892646],"domain_scores_gemma":[0.9995078,0.0002528085,0.00007058545,0.00001464555,0.000103866,0.00005035031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003035538,0.0001646146,0.0001319347,0.01417253,0.000143082,0.0001379617,0.00003740717,0.0004497396,0.002294075,0.002853066,0.02727485,0.9520372],"study_design_scores_gemma":[0.0001345573,0.000349937,0.0006150155,0.004021184,0.0003635471,0.0007748927,0.00004851618,0.0002088492,0.0009147651,0.002058668,0.9904838,0.00002629661],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009458546,0.9987922,0.0001260175,0.0003040906,0.0001991166,0.00000537666,0.00002067487,0.000008297094,0.0004496588],"genre_scores_gemma":[0.0007347236,0.9978486,0.0002945767,0.0003673226,0.0002357021,0.00001016858,0.0000330822,0.000002267334,0.0004735799],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003744789,"threshold_uncertainty_score":0.01252753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05452225443549843,"score_gpt":0.3243609393276801,"score_spread":0.2698386848921817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}