{"id":"W4379114671","doi":"10.1016/s1470-2045(23)00242-5","title":"Zanidatamab for HER2-amplified, unresectable, locally advanced or metastatic biliary tract cancer (HERIZON-BTC-01): a multicentre, single-arm, phase 2b study","year":2023,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":247,"is_retracted":false,"has_abstract":false,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Medicine; Internal medicine; Cohort; Tolerability; Biliary tract cancer; Clinical endpoint; Oncology; Cancer; Response Evaluation Criteria in Solid Tumors; Biliary tract; Gastroenterology; Immunohistochemistry; Gemcitabine; Phases of clinical research; Clinical trial; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00220089,0.001871973,0.002539643,0.0004847975,0.0004023995,0.001372372,0.0009618574,0.001451591,0.005028884],"category_scores_gemma":[0.001233195,0.0008305768,0.002426233,0.0006895015,0.00091061,0.001127479,0.0004080891,0.003380341,0.001071668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001077506,"about_ca_system_score_gemma":0.001253955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00226835,"about_ca_topic_score_gemma":0.008144056,"domain_scores_codex":[0.9994313,0.0002748969,0.00002437212,0.00008108876,0.00005628457,0.0001320266],"domain_scores_gemma":[0.9993536,0.0001218334,0.0001806217,0.00006903306,0.00004167864,0.000233222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9038312,0.0115144,0.004069702,0.002032557,0.005110838,0.000131502,0.0002044642,0.00163925,0.009165335,0.0003518502,0.004183011,0.05776585],"study_design_scores_gemma":[0.9198495,0.06511051,0.008964467,0.00006903342,0.002284335,0.0001277268,0.00007377613,0.000440054,0.0005874016,0.0002024901,0.00225592,0.00003472589],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799454,0.01129588,0.0006029727,0.0009364348,0.0003295417,0.001701371,0.00236382,0.0001159918,0.002708534],"genre_scores_gemma":[0.973598,0.01180741,0.001647339,0.001703484,0.0002290246,0.00165268,0.003608983,0.00007771213,0.005675427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005028884,"threshold_uncertainty_score":0.01682323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1648648786977995,"score_gpt":0.4350447860106897,"score_spread":0.2701799073128902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}