{"id":"W4379114671","doi":"10.1016/s1470-2045(23)00242-5","title":"Zanidatamab for HER2-amplified, unresectable, locally advanced or metastatic biliary tract cancer (HERIZON-BTC-01): a multicentre, single-arm, phase 2b study","year":2023,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":247,"is_retracted":false,"has_abstract":false,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Medicine; Internal medicine; Cohort; Tolerability; Biliary tract cancer; Clinical endpoint; Oncology; Cancer; Response Evaluation Criteria in Solid Tumors; Biliary tract; Gastroenterology; Immunohistochemistry; Gemcitabine; Phases of clinical research; Clinical trial; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008764564,0.0004062538,0.001421341,0.0001504362,0.0003044121,0.00003910146,0.0004351847,0.0001051676,0.0003797675],"category_scores_gemma":[0.0005885277,0.0002514809,0.0001887595,0.0008118736,0.0002108805,0.0001270551,0.0001980426,0.0004334163,0.00007792121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003923163,"about_ca_system_score_gemma":0.0005823263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004972114,"about_ca_topic_score_gemma":0.004475225,"domain_scores_codex":[0.9970219,0.000298741,0.0005862979,0.0006947044,0.0003679438,0.001030432],"domain_scores_gemma":[0.9968816,0.001662373,0.0002451643,0.0008204391,0.0002032818,0.0001871619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1224715,0.04050116,0.03132331,0.002433141,0.006637341,0.004322937,0.03231204,0.0005697379,0.02516306,0.0002049203,0.2413577,0.4927031],"study_design_scores_gemma":[0.1869313,0.06390268,0.06365952,0.000517963,0.004804386,0.0003991099,0.04543944,0.004106669,0.00216695,0.0004482823,0.626195,0.001428782],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705557,0.003013845,0.0004424939,0.01525989,0.001660882,0.006397767,0.0005564067,0.0004882626,0.001624807],"genre_scores_gemma":[0.9886587,0.001097064,0.001103728,0.002825332,0.001277647,0.002424546,0.0001566152,0.0001012026,0.002355157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4912743,"threshold_uncertainty_score":0.9999937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1648648786977995,"score_gpt":0.4350447860106897,"score_spread":0.2701799073128902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}